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Hematology
Hematology

Hematology

Basic Principles and Practice

9780443066283
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Description
The fourth edition of this leading text reflects the new direction and growth of the field of haematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of haematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in haematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing haematologist.
Hematology:: Basic Prinicples and Practice 4th Edition is now available as an e-dition - the 2-volume book plus state-of-the-art website featuring the full text online and many extra features. Click through to related titles for more information.
Product Details
Churchill Livingstone
33019
9780443066283
9780443066283

Data sheet

Publication date
2005
Issue number
4
Cover
hard cover
Pages count
2864
Dimensions (mm)
216 x 276
Weight (g)
5357
  • Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY


    Chapter 1 Anatomy and Physiology of the Gene
    Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner


    Chapter 2 Genomic Approaches to the Study of Hematologic Science
    Todd Golub and Scott Armstrong


    Chapter 3 Protein Synthesis, Processing, and Degradation
    Garabet G. Toby and David L. Wiest


    Chapter 4 Protein Architecture: Relationship of Form and Function
    Alan C. Rigby and Barbara C. Furie


    Chapter 5 Regulation of Cellular Response
    Benjamin G. Neel and Christopher Carpenter


    Chapter 6 Cell Adhesion
    Rodger P. McEver


    Chapter 7 Control of Cell Division
    William M.F. Lee and Chi V. Dang


    Chapter 8 Cell Death
    David M. Hockenbery and Stanley J. Korsmeyer


    Chapter 9 Pharmacogenomics and Hematological Diseases
    Loe Kager and William E. Evans


    Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY


    Chapter 10 Overview and Compartmentalization of the Immune System
    Leland D. Powell and Linda G. Baum


    Chapter 11 B-Cell Development
    Kenneth Dorshkind and David J. Rawlings


    Chapter 12 T-Cell and NK-Cell Immunity
    Carol Clayberger and Alan M. Krensky


    Chapter 13 Dendritic Cell Biology
    Zbigniew M. Szczepiorkowski and Nina Bhardwhaj


    Chapter 14 Regulation of Activation of B and I Lymphocytes
    John C. Monroe and Lawrence Turka


    Chapter 15 Leukocyte Trafficking
    James J. Campbell, Steven Sloan, and Leslie E. Silberstein


    Chapter 16 Tolerance and Autoimmunity
    Mark J. Shlomchik


    Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS


    Chapter 17 Stem Cell Model of Hematopoiesis
    Anskar YH Leung and Catherine M. Verafaillie


    Chapter 18 Bone Marrow Microenvironment
    Mo Dao and Catherine M. Verfaillie


    Chapter 19 The Humeral Regulation of Hematopoiesis
    Montaser Shaheen and Hal Broxmeyer


    Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
    Thalia Papayannopoulou, Alan DAndrea, Janis Abkowitz, and Anna Rita Migliaccio


    Chapter 21 Granulopoiesis and Monocytopoiesis
    Arati Khanna-Gupta and Nancy Berliner


    Chapter 22 Thrombocytopoiesis
    Michael W. Long and Ronald Hoffman


    Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
    J. B. Opalinska and Alan M. Gewirtz


    Chapter 24 Inherited Forms of Bone Marrow Failure
    Melvin H. Freedman


    Chapter 25 Aplastic Anemia
    Neal S. Young and Jaroslaw P. Maciejewski


    Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
    Rob A. Brodsky


    Chapter 27 Pure Red Cell Aplasia
    Emmanuel N. Dessypris


    Part IV. RED BLOOD CELLS


    Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
    Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert


    Chapter 29 Approach to Anemia in the Adult and Child
    Peter Marks and Bertil Glader


    Chapter 30 Anemia of Chronic Diseases
    Lawrence B. Gardner and Edward J. Benz, Jr.


    Chapter 31 Pathology of Iron Metabolism
    Nancy C. Andrews


    Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload
    Gary M. Brittenham


    Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
    James S. Wiley and Michael R. Moore


    Chapter 34 Megablastic Anemias
    Aook C. Anthony


    Chapter 35 Thalassemia Syndromes
    Bernard G. Forget and Alan R. Cohen


    Chapter 36 Pathology of Sickle Cell Disease
    Robert P. Hebbel


    Chapter 37 Sickle Cell Disease
    Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah


    Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and
    Methemoglobinemias
    Edward J. Benz, Jr.


    Chapter 39 Red Cell Enzymopathies
    Xylina T. Gregg and Josef T. Prchal


    Chapter 40 Red Cell Membrane Disorders
    Patrick G. Gallagher and Petr Jarolim


    Chapter 41 Autoimmune Hemolytic Anemias
    Melody J. Cunningham and Leslie E. Silberstein


    Chapter 42 Extrinsic Nonimmune Hemolytic Anemias
    Stanley L. Schrier and Erin Gourley Reid

    Part V. HOST DEFENSE AND ITS DISORDERS


    Chapter 43 Complement Biology and Immunoglobulin
    Gregory Kline, Robert Barrington, and Michael C. Carroll


    Chapter 44 Normal Phagocyte Structure and Function
    Robert L. Baehner


    Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
    Steven J. Ackerman and Joseph H. Butterfield


    Chapter 46 Disorders of Phagocyte Function and Number
    Mary C. Dinauer and Thomas D. Coates


    Chapter 47 Disorders of Lymphocyte Function
    Aileen M. Cleary, Richard A. Insel, and David B. Lewis


    Chapter 48 Histiocytic Disorders
    Jeffrey M. Lipton and Robert J. Arceci


    Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
    Gregory A. Grabowski and Nancy Leslie


    Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
    Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop


    Chapter 51 The Spleen and Its Disorders
    Susan B. Shurin


    Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis
    Robert I. Parker and Dean D. Metcalfe


    Part VI. HEMATOLOGIC MALIGNANCIES


    Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological
    Malignancies
    Gordon Dewald and Rhett P. Ketterling


    Chapter 54 The Molecular Basis of Neoplasia
    Carol Westbrook


    Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
    Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis



    Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
    Andrea K. Ng and Peter M. Mauch


    Chapter 57 Clinical Use of Hematopoietic Growth Factors
    Jacob M. Rowe and Irit Avivi


    Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
    Thomas E. Witzig


    Chapter 59 Pathobiology of Acute Myeloid Leukemia
    Brian Huntly and D. Gary Gilliland


    Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
    Kenneth B. Miller and Philip R. Daoust


    Chapter 61 Therapy for Acute Myeloid Leukemia
    Elihu H. Estey and Hagop Kantarijan


    Chapter 62 Acute Myeloid Leukemia in Children
    Gary V. Dahl and Howard J. Weinstein


    Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
    A. Thomas Look and Adolpho Ferrando


    Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
    Stacey L. Berg, C. Philip Steuber, and David G. Poplack


    Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
    Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen


    Chapter 66 Acute Lymphoblastic Leukemia in Adults
    Dieter Hoelzer and Nicola Gokbudget


    Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
    Richard Stone and Daniel DeAngelo


    Chapter 68 Polycythemia Vera
    Ronald Hoffman, Kelty R. Baker and Joe Prchal


    Chapter 69 Chronic Myeloid Leukemia
    Charles Sawyers and Neil P. Shah


    Chapter 70 Myelofibrosis with Myeloid Metaplasia
    Ronald Hoffman and Farhad Ravandi-Kashani


    Chapter 71 Essential Thrombocythemia
    Steven Fruchtman and Ronald Hoffman


    Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
    David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz


    Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
    Gianluca Gaidano and Riccardo Dalla-Favera


    Chapter 74 Patho-Biology of Hodgkins Lymphoma
    Stefano A. Pileri, Brunangelo Falini and Harold Stein


    Chapter 75 Hodgkins Disease: Clinical Manifestations, Staging, and Therapy
    Volker Diehl, Daniel Re, and Andreas Josting


    Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
    Elaine Jaffe and Stefania Piltaluga


    Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce


    Chapter 78 Malignant Lymphomas in Childhood
    John T. Sandlund, Jr.Michael P. Link


    Chapter 79 Chronic Lymphocytic Leukemia
    Dilip V. Patel and Kanti R. Rai


    Chapter 80 Hairy Cell Leukemia
    Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman


    Chapter 81 Cutaneous T-Cell Lymphomas
    Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen


    Chapter 82 AIDS-Related Lymphomas
    David T. Scadden


    Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
    Guido Tricot


    Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
    Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien


    Chapter 85 Atypical Immune Lymphoproliferations
    Timothy C. Greiner and Thomas G. Gross


    Chapter 86 Clinical Approaches to Infections in the Compromised Host
    Jo-Anne H. van Burik


    Chapter 87 Nutritional Support of Patients with Hematologic Malignancies
    Polly Lenssen and Saundra N. Aker


    Chapter 88 Psychosocial Aspects of Hematologic Disorders
    Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta


    Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders
    Janet L. Abrahm, Lauren Dias, and Bridget Fowler


    Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes


    Chapter 91 Indwelling Access Devices
    Janet L. Abrahm and Linda M. Pellerin


    Chapter 92 Late Complications of Hematologic Diseases and Their Therapies
    Wendy Landier and Smita Bhatia


    Part VII. TRANSPLANTATION


    Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
    William Tse and H. Joachim Deeg


    Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
    Stella M. Davies


    Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
    Andrea Bacigalupo


    Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors
    Stephen J. Forman and Jeffery R. Schriber


    Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy
    Effie W. Petersdorf and Claudio Anasetti


    Chapter 98 Umbilical Cord Blood Transplantation
    Juliet N. Barker and John E. Wagner


    Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation
    Marcos de Lima and Sergio Giralt


    Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia
    Pavan Reddy and James L.M. Ferrara


    Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
    Catherine M. Bollard and Adrian P. Gee


    Chapter 102 Gene Transfer for Hematologic Disorders
    Katherine A. High and Malcolm K. Brenner


    Chapter 103 Experimental Cell Therapy
    Robert S. Negrin


    Chapter 104 Complications After Hematopoietic Cell Transplantation
    Daniel J. Weisdorf


    Part VIII. HEMOSTASIS AND THROMBOSIS


    Chapter 105 Megakaryocyte and Platelet Structure
    Joseph E. Italiano and John Hartwig


    Chapter 106 The Molecular Basis for Platelet Function
    Edward F. Plow and Charles S. Abrams


    Chapter 107 The Molecular Basis for Platelet Activation
    Lawrence F. Brass


    Chapter 108 The Blood Vessel Wall
    Aly Karsan and John M. Harlan


    Chapter 109 Molecular Basis of Blood Coagulation
    Bruce Furie and Barbara C. Furie


    Chapter 110 Molecular and Cellular Basis of Fibrinolysis
    H. Roger Lijnen and Désiré Collen


    Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
    Charles T. Esmon


    Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential
    Diagnosis of Pupura
    Barry S. Coller and Paul I. Schniederman


    Chapter 113 Laboratory Evaluation of Hemostatic Disorders
    Jacob H. Rand and Lisa Senzel



    Chapter 114 Structure, Biology, and Genetics of Factor VIII
    Randal J. Kaufman and Stylianos E. Antonarakis


    Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B
    S. Jamie Freedman and Bruce Furie


    Chapter 116 Clinical Aspects and Therapy of Hemophilia
    Jay Nelson Lozier and Craig M. Kessler


    Chapter 117 Inhibitors in Hemophilia
    Donald I. Feinstein


    Chapter 118 Other Clotting Factor Deficiencies
    Harold R. Roberts and Miguel A. Escobar


    Chapter 119 Disorders of Fibrinogen
    José Martinez and Andres Ferber


    Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor
    David Ginsburg and Denisa D. Wagner


    Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy
    Gilbert C. White, II, and J. Evan Sadler


    Chapter 122 Vitamin K: Metabolism and Disorders
    Barbara C. Furie and Bruce Furie


    Chapter 123 Inhibitors of Blood Coagulation
    Donald I. Feinstein


    Chapter 124 Disseminated Intrvascular Coagulation
    Howard A. Liebman and Ilene C. Weitz


    Chapter 125 Hemostatic Defects Associated with Dysproteinemias
    Howard A. Liebman


    Chapter 126 Disorders of Coagulation in the Neonate
    Leonardo R. Brandao and Donna DiMichele


    Chapter 127 Hypercoagulable States
    Kenneth A. Bauer


    Chapter 128 Venous Thromboembolism
    Mark A. Crowther and Jeffrey S. Ginsberg


    Chapter 129 Arterial Thromboembolism
    Mark A. Crowther and Jeffrey S. Ginsberg


    Chapter 130 Anticoagulation and Thrombolytic Therapy
    Jeffrey I. Weitz


    Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune
    Thrombocytopenia, and Posttransfusion Purpura
    James Bussel and Douglas Cines


    Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
    Keith R. McCrae, J Evan Sadler, and Douglas Cines


    Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism
    Theodore E. Warkentin and John G. Kelton


    Chapter 134 Hereditary Disorders of Platelet Function
    Joel S. Bennett


    Chapter 135 Acquired Disorders of Platelet Function
    Jose Lopez and Perumal Thiagarajan


    Part IX. TRANSFUSION MEDICINE


    Chapter 136 Human Blood Group Anitgens and Antibodies
    Part 1: Carbohydrate Determinants
    Part 2: Protein Determinants
    Marion E. Reid and Martin L. Olsson


    Chapter 137 Human Platelet Antigens
    Thomas J. Kunicki and Diane J. Nugent


    Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek


    Chapter 139 Principles of Red Blood Cell Transfusion
    Paul M. Ness and Margot S. Kruskall


    Chapter 140 Principles of Platelet Transfusion Therapy
    Thomas S. Kickler


    Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions
    Ronald G. Strauss


    Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,
    Cryoprecipitate, Albumin, and Immunoglobulins
    Cassandra D. Josephson and Christopher D. Hillyer


    Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
    William N. Drohan and David B. Clark


    Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies
    Catherine S. Manno and Peter Larson


    Chapter 145 Hemapheresis and Cellular Therapy
    Ellen F. Lazarus and Harvey G. Klein


    Chapter 146 Practical Aspects of Stem Cell Collection
    Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu


    Chapter 147 Transfusion Reactions
    Edward L. Snyder and YanYun Wu


    Chapter 148 Transfusion-Transmitted Diseases
    Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove


    Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik


    Chapter 150 Red Blood Cell Substitutes
    Robert M. Winslow


    Part X. CONSULTATIVE HEMATOLOGY


    Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
    Rachel Rosovsky and Peter W. Marks


    Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
    Peter W. Marks and David S. Rosenthal


    Chapter 153 Hematologic Manifestations of AIDS
    David H. Henry and James A. Hoxie


    Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
    Mark T. Reding and Nigel S. Key


    Chapter 155 Hematologic Aspects of Pregnancy
    Edward J. Benz, Jr.


    Chapter 156 Hematologic Manifestations of Childhood Illness
    A. Kim Ritchey and Frank G. Keller


    Part XI. SPECIAL TESTS AND PROCEDURES


    Chapter 157 Bone Marrow Examination
    Daniel H. Ryan and Harvey J. Cohen


    Chapter 158 Automated Analysis of Blood Cells
    Raymond E. Felgar and Daniel H. Ryan


    Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias
    Martin H. Steinberg and David Chui


    Chapter 160 Antenatal Diagnosis of Hematologic Disorders
    Kim Kramer and Harvey J. Cohen


    Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases
    Michele Paessler and Adam Bagg


    Chapter 162 Molecular Imaging in Hematology
    Francis G. Blankenberg


    Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
    Sharon M. Geaghan

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Hematology
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