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Hematology

Hematology

Basic Principles and Practice

9780323733885
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Description
Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource.
Product Details
Elsevier
94011
9780323733885
9780323733885

Data sheet

Publication date
2022
Issue number
8
Cover
hard cover
Pages count
2512
Dimensions (mm)
216 x 276
Weight (g)
5120
  • PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
    1. Anatomy and Physiology of the Gene
    2. Epigenomics in Hematology
    3. Genomic Approaches to Hematology
    4. Regulation of Gene Expression in Hematology
    5. Genome Editing
    6. Signaling Transduction and Metabolomics
    7. Protein Architecture: Relationship of Form and Function
    8. Pharmacogenomics and Hematologic Diseases
    PART II CELLULAR BASIS OF HEMATOLOGY
    9. Hematopoietic Stem Cell Biology
    10. Mitochondria and Hematopoiesis
    11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors
    12. Role of Chemokines in Leukocyte Trafficking
    13. Stem Cell Model of Hematologic Diseases
    14. Hematopoietic Microenvironment
    15. Cell Adhesion
    16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
    17. Control of Cell Division
    18. Cell Death
    19. Aging and Hematopoiesis
    PART III IMMUNOLOGIC BASIS OF HEMATOLOGY
    20. Dendritic Cell Biology
    21. Natural Killer Cell Immunity and Therapy
    22. B-Cell Development
    23. Complement and Immunoglobulin Biology Leading to Clinical Translation
    24. T-Cell Immunity
    25. Unmodified Ex Vivo Expanded T Cells
    26. Treatment of Hematologic Malignancies with Genetically Modified T Cells
    PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT
    27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
    28. Granulocytopoiesis and Monocytopoiesis
    29. Thrombocytopoiesis
    30. Inherited Bone Marrow Failure Syndromes
    31. Aplastic Anemia
    32. Paroxysmal Nocturnal Hemoglobinuria
    33. Acquired Disorders of Red Cell, White Cell, and Platelet Production
    PART V RED BLOOD CELLS
    34. Pathobiology of the Human Erythrocyte and Its Hemoglobins
    35. Approach to Anemia in the Adult and Child
    36. Iron Homeostasis and Its Disorders
    37. Disorders of Iron Homeostasis: Iron Deficiency and Overload
    38. Anemia of Chronic Inflammation
    39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
    40. Megaloblastic Anemias
    41. Thalassemia Syndromes
    42. Pathobiology of Sickle Cell Disease
    43. Clinical Aspects of Sickle Cell Disease
    44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
    45. Red Blood Cell Enzymopathies
    46. Red Blood Cell Membrane Disorders
    47. Autoimmune Hemolytic Anemia
    48. Extrinsic Nonimmune Hemolytic Anemias
    PART VI NON-MALIGNANT LEUKOCYTES
    49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia
    50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
    51. Disorders of Phagocyte Function
    52. Congenital Disorders of Lymphocyte Function
    53. Pediatric and Adult Histiocytic Disorders
    54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles
    55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions
    PART VII HEMATOLOGIC MALIGNANCIES
    56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
    57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies
    58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
    59. Pathobiology of Acute Myeloid Leukemia
    60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
    61. Myelodysplastic Syndromes
    62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
    63. Acute Myeloid Leukemia in Children
    64. Blastic Plasmacytoid Dendritic Cell Neoplasm
    65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children
    66. Pathobiology of Acute Lymphoblastic Leukemia
    67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia
    68. Acute Lymphoblastic Leukemia in Adults
    69. Chronic Myeloid Leukemia
    70. The Polycythemias
    71. Essential Thrombocythemia
    72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia
    73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes
    74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes
    75. Mast Cells and Mastocytosis
    76. Chronic Lymphocytic Leukemia
    77. Hairy Cell Leukemia
    78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
    79. Origin of Hodgkin Lymphoma and Therapeutic Targets
    80. Hodgkin Lymphoma
    81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets
    82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
    83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)
    84. Diffuse Large B-Cell Lymphoma of the Central Nervous System
    85. High-Grade B-Cell Lymphomas
    86. Mantle Cell Lymphoma
    87. Virus-Associated Lymphoma
    88. Malignant Lymphomas in Childhood
    89. T-Cell Lymphomas
    90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
    91. Multiple Myeloma
    92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma
    93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
    PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES
    94. Key Considerations for Managing Infections in the Compromised Host
    95. Principles of Radiation Therapy for Hematologic Disease
    96. Grading and Toxicity Management after Immune Effector Therapy
    97. Identification and Management of Checkpoint Inhibition Toxicity
    98. Psychosocial Aspects of Hematologic Disorders
    99. Pain Management and Antiemetic Therapy in Hematologic Disorders
    100. Palliative Care
    101. Therapy-related Late Effects of Hematologic Malignancies
    PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES
    102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization
    103. Graft Engineering and Cell Processing
    104. Principles of Cell-Based Genetic Therapies
    105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
    106. Unrelated Donor Hematopoietic Cell Transplantation
    107. Haploidentical Hematopoietic Stem Cell Transplantation
    108. Cord Blood Transplantation
    109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses
    110. Supportive Care for the Transplant Patient
    PART X TRANSFUSION MEDICINE
    111. Human Blood Group Antigens and Antibodies
    112. Principles of Red Blood Cell Transfusion
    113. Clinical Considerations in Platelet Transfusion Therapy
    114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems
    115. Principles of Plasma and Plasma Derivatives
    116. Hemapheresis
    117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products
    118. Transfusion-Transmitted Diseases
    119. Pediatric Transfusion Medicine
    120. Transfusion and Apheresis Support for Sickle Cell Disease Patients
    PART XI HEMOSTASIS AND THROMBOSIS
    121. Overview of Hemostasis and Thrombosis
    122. Blood Vessels
    123. Megakaryocyte and Platelet Structure
    124. Molecular Basis of Platelet Function
    125. Molecular Basis of Blood Coagulation
    126. Evaluation of the Patient with Suspected Bleeding Disorders
    127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders
    128. Acquired Disorders of Platelet Function
    129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
    130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution
    131. Heparin-Induced Thrombocytopenia
    132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
    133. Structure, Biology, and Genetics of von Willebrand Factor
    134. Hemophilia A and B
    135. Rare Coagulation Factor Deficiencies
    136. Transfusion Therapy for Coagulation Factor Deficiencies
    137. Disseminated Intravascular Coagulation
    138. Hypercoagulable States
    139. Antiphospholipid Syndrome
    140. Venous Thromboembolism
    141. Prevention and Treatment of Venous Thromboembolism in Pregnancy
    142. Atherothrombosis
    143. Antithrombotic Drugs
    144. Stroke
    145. Acute Coronary Syndromes
    146. Peripheral Artery Disease
    147. Atrial Fibrillation
    148. Bleeding and Clotting Disorders in Pediatrics
    PART XII CONSULTATIVE HEMATOLOGY
    149. Hematologic Changes in Pregnancy
    150. Hematologic Manifestations of End-Organ Failure
    151. Hematologic Manifestations of Solid Tumors
    152. Hematologic Manifestations of HIV/AIDS
    153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection
    154. Hematologic Aspects of Parasitic Diseases
    155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
    156. The Spleen and Its Disorders
    157. Aging and Hematologic Disorders
    158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments
    159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1
    Chapter 159 can be found online at Elsevier digital versions for Practicing Clinicians
    Index
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