In one place hepatologists can now find information about the most difficult-to-treat clinical problems. The Guest Editors have assembled expert authors to write about fulminant hepatic failure, pruritus of cholestasis, gastroesophageal varices, treatment of HCV after liver transplantation, and the HBV-infected patient with resistance, to name a few. This issue is a must have for the practicing hepatologist. Key words:: pruritis of cholestasis, liver transplantation, Budd-Chiari syndrome, hepatocellular carcinoma, alcoholic hepatitis, gastroesphageal varices.