In this issue of Veterinary Clinics:: Exotic Animal Practice, guest editor Dr. Alyssa Scagnelli brings her considerable expertise to the topic of Updates in Internal Medicine. Top experts in the field provide an in-depth update on internal medicine of zoological species, with emphasis on companion zoological animals. Articles include relevant anatomy and physiology, laying a foundational understanding for diagnostics and treatment, and provide a systems-based review and update of clinical conditions across a range of species.