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Molecular Toxicology
9780195176209
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Description
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis of enzymes of biotransformation; and molecular toxicology of aromatic amines, nirosamines, polycyclic aromatic hydrocarbons, chlorinated compounds.
Product Details
84550
9780195176209
9780195176209
Data sheet
- Publication date
- 2006
- Issue number
- 2
- Cover
- hard cover
- Pages count
- 608
- Dimensions (mm)
- 187 x 260
- Weight (g)
- 1247
- Act One: Toxicity at the Cellular Level; Toxicology of oxygen; Covalent Binding of Xenobiotics to DNA and Protein; DNA Repair; Chemical Mutagenesis; Oncogenes, tumor suppressor genes, and mutations in cancer cells; tumors; Toxicity, survival, and target theory; Act Two: Enzymology of Biotransformation; Cytochrome P450 - Chemical and Biochemical Aspects; P450: Biological aspects; regulation; genetics; Biochemistry of glutathione; Glutathione transferases; Glutathione and glutathione transferases: Toxicological and pharmacological aspects; Glucuronidation; Arylamine N-Acetyltransferase; Sulfotransferase; Act Three: Molecular Principles Applied to Specific Toxicants; Alkylating agents and mustards; Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia; Aromatic amines and related toxic compounds; Polycyclic aromatic hydrocarbon carcinogens; Acetaminophen;
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