This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis of enzymes of biotransformation; and molecular toxicology of aromatic amines, nirosamines, polycyclic aromatic hydrocarbons, chlorinated compounds.
Act One: Toxicity at the Cellular Level; Toxicology of oxygen; Covalent Binding of Xenobiotics to DNA and Protein; DNA Repair; Chemical Mutagenesis; Oncogenes, tumor suppressor genes, and mutations in cancer cells; tumors; Toxicity, survival, and target theory; Act Two: Enzymology of Biotransformation; Cytochrome P450 - Chemical and Biochemical Aspects; P450: Biological aspects; regulation; genetics; Biochemistry of glutathione; Glutathione transferases; Glutathione and glutathione transferases: Toxicological and pharmacological aspects; Glucuronidation; Arylamine N-Acetyltransferase; Sulfotransferase; Act Three: Molecular Principles Applied to Specific Toxicants; Alkylating agents and mustards; Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia; Aromatic amines and related toxic compounds; Polycyclic aromatic hydrocarbon carcinogens; Acetaminophen;
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