In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Consuelo C. Cagande, Lisa Fortuna, and Elizabeth McGuire bring their considerable expertise to the topic of Transforming Systems of Care for Girls. Systems of care for girls is an increasingly important area within child and adolescent psychiatry, with a focus on understanding the unique mental health needs and challenges faced by girls, which are often distinct from those of boys. In this issue, top experts provide timely guidance to help create more effective, equitable, and supportive environments-essential not only for improving individual outcomes but also for fostering healthier communities and societies as a whole.