In this issue of Pediatric Clinics of North America, guest editors Drs. Paul E. Weigel and Erin Lechner Belfort bring their considerable expertise to the topic of Social Media and Pediatric Mental Health. Social media habits and interactions are of increasing importance in the lives of youth and are increasingly significant for their mental health and treatment. This issue will leverage the current state of scientific literature and the authors’ clinical experience to explore the many ways social media impacts mental health for better and worse, and how pediatricians should evaluate and address them in clinical practice.