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Drug Safety
From Molecule to Man
9780443071348
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Description
This book describes the basic principles of adverse drug reactions, their clinical manifestations in the various body systems, and how adverse drug reactions are detected and prevented. Throughout the emphasis is on the human clinical situation.
Product Details
32051
9780443071348
9780443071348
Data sheet
- Publication date
- 2007
- Issue number
- 1
- Cover
- paperback
- Pages count
- 288
- Dimensions (mm)
- 156 x 234
- Part I: Basic concepts
Defintion of terms. Classification of ADRs. Epidemiology of ADRs. Importance of ADRs to health and health care. Clinical apsects of ADRs.
Part II: Mechanisms of ADRs
Relevance of primary and secondary pharmacology. Relevance of drug metabolism and pharmacokinetics.Pre-clinical toxicology . Drugs and reproductive toxicology. Drugs and carcinogenicity. Type A reactions and prediposing factors. Drug interactions and ADRs. Type B reactions: different postulated mechanisms. Immune mediated ADRs: the hapten hypothesis. Pharmacogenetics and ADRs.
Part III: ADRs by systems
Liver. Haematological system. Skin. Kidneys. Lung. Heart. Central and peripheral nervous system. Eyes.
Part IV: Pharmacovigilance
Spontaneous ADR reporting. Record Linkage databases. GPRD. Conventional pharmacoepidemiological studies.
Part V: Prevention of ADRs
Chemical solutions. Genetic solutions. Epidemiological solutions.
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