Together with Consulting Editor Dr. Lucky Jain, Dr. Sudarshan R. Jadcherla has put together a comprehensive issue devoted to neonatal gastroenterology. Expert authors have contributed clinical review articles on the following topics:: Neonatal Aerodigestive Disorders:: Epidemiology and Economic Burden; Feeding and Swallowing Difficulties in Neonates:: Developmental Physiology and Pathophysiology; Gastroesophageal Reflux Disease in the NICU Neonate:: Controversies, Current Understanding and Future Directions; Feeding Difficulties and Tube-feeding Controversies in Complex Neonates:: Evidence-Based Practices; Physiology and Pathological basis of Aerodigestive Difficulties in Chronic Lung Disease; Congenital Diarrheas in Infants:: Pathophysiology, Consequences, and Potential Treatment Strategies; Short Gut syndrome:: Recent Advances in Pathophysiology and Intestinal Support Practices; Neonatal Cholestasis in the Premature Infant:: Approaches to Diagnosis and Management; Strategies for Prevention of TPN-related Liver Injury; Supplements and Additives to Human Milk:: Principles and Practices, Current Controversies; Microbiome and Gut Injury in Neonates; Recent Advances in NEC Research:: Strategies for Implementation in Clinical Practice; Transfusion-Related Gut Injury and NEC; Neonatal Endoscopy, Diagnosis and Intervention Procedures Crib-side; and Surgical Gastrointestinal Emergencies in Neonates:: An overview. Readers will come away with the information they need to improve outcomes in the neonate.