The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

GENERAL CONCEPTS OF MECHANISMS OF DISEASE:: Repeat Expansion Disorders:: General Concepts and Mechanisms of Disease / Mendelian, Nonmendelian, Multigenic Inheritance, and Complex Traits / Selected Genetically Engineered Models Relevant to Human Neurodegenerative Disease / Gene Mapping to Gene Targeting:: Application of Mouse Genetics to Human Disease / Human Genomics and Disease / Gene Therapy for Central Nervous System Disorders / Emerging Ethical Issues in Neurology, Psychiatry, and the Neurosciences / Genotype-Phenotype Correlations
NEUROLOGIC DISEASES:: Down Syndrome / Triplet Repeat Diseases:: Genetics, Clinical Features, and Pathogenesis / Prion Diseases
Mitochondrial Disorders:: The Mitochondrial Genome / Mitochondrial Disorders Due to Mutations in the Mitochondrial Genome / Mitochondrial Disorders Due to Mutations in the Nuclear Genome / Mitochondria in Neurodegenerative Disorders
Peroxisomal Disorders:: Perioxisomal Disorders
Lysosomal Disorders:: Gaucher Disease / The Niemann-Pick Diseases / The Gm2-Gangliosidoses / Metachromatic Leukodystrophy and Multiple Sulfatase Deficiency:: Sulfatide Lipidosis / Krabbe Disease:: Globoid Cell Leukodystrophy / The Mucopolysaccharidoses and the Mucolipidoses / Disorders of Glycoprotein Degradation:: Sialidosis, Fucosidosis, Alpha-Mannosidosis, Beta- / Beta-Galactosidase Deficiency:: GM1 Gangliosidosis, Morquio B Disease, and Galactosialidosis / Farber Disease:: Acid Ceramidase Deficiency, Farber Lipogranulomatosis / Wolman Disease / Lysosomal Membrane Disorders:: LAMP-2 Deficiency / Fabry Disease:: Alpha Galactosidase A Deficiency / Schindler Disease:: Deficient Alpha-N-Acetylgalacosaminidase Activity
Degenerative Disorders:: Alzheimers Disease / Frontotemporal Dementias / Genetics of Movement Disorders / The Inherited Ataxias / Canavan Disease / Hereditary Spastic Paraplegia
Neuro-Oncology:: Neuro-Oncology:: The Neurofibromatoses
Epilepsy:: The Genetic Epilepsies
Demyelinating Disease:: Demyelinating Diseases
Neuropathies and Neuronopathies:: Peripheral Neuropathies / The Molecular and Genetic Basis of Spinal Muscular Atrophies
Congenital Myasthenic Syndromes:: Congenital Myasthenic Syndromes
Myopathies:: Dystrophinopathies / Limb-Girdle Muscular Dystrophies / The Congenital Myopathies / The Distal Myopathies / Hereditary Inclusion-Body Myopathies / The Myotonic Dystrophies / Facioscapulohumeral Dystrophy / Ion Channel Disorders
Dermatologic and Brain Disorders:: The Phakomatoses / Lipoprotein Disorders / Apolipoprotein E:: Structure and Function in Lipid Metabolism and Neurobiology / Cerebrotendinous Xanthomatosis
Metabolic Disorders:: Disorders of Lipid Metabolism / Glycogen Storage Diseases / Disorders of Galactose Metabolism / Inborn Errors of Amino Acid Metabolism / Disorders of the Urea Cycle / Disorders of Glucose Transport / Maple Syrup Urine Disease:: Clinical and Biochemical Perspectives / Congenital Disorders of N-linked Glycosylation / Disorders of Glutathione Metabolism
Purines:: Purines
Porphyrias:: The Porphyrias
Metal Metabolism:: Friedreich Ataxia / Disorders of Copper Metabolism:: Wilson Disease and Menkes Disease
Vitamins:: Genetic and Dietary Influences on Life Span / Vitamins:: Cobalamin and Folate / Disorders of Biotin Metabolism:: Treatable Neurologic Syndromes
PSYCHIATRIC DISEASE:: Psychiatric Diseases:: Challenges in Psychiatric Genetics / Depression / Bipolar Disorder / Schizophrenia / Obsessive-Compulsive Disorder and Tourettes Syndrome / Genetic Bases of Addictive Behaviors / Autism
A NEUROLOGIC GENE MAP:: A Neurologic Gene Map