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The Molecular and Genetic Basis of Neurologic and Psychiatric Disease
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Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development.
This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues. Six new chapters cover congenital myasthenic syndromes, hereditary spastic paraplegia, ion channel disorders, the phakomatoses, beta-galactosidase deficiency, and prion diseases. A Neurologic Gene Map describes the chromosome locus of all the genetic diseases and their gene product where known.
The fully searchable online text is available on a companion Website.
Opis
- Rok wydania
- 2007
- Numer wydania
- 4
- Oprawa
- twarda
- Liczba stron
- 912
- Wymiary (mm)
- 216 x 279
- Waga (g)
- 2041
GENERAL CONCEPTS OF MECHANISMS OF DISEASE:: Repeat Expansion Disorders:: General Concepts and Mechanisms of Disease / Mendelian, Nonmendelian, Multigenic Inheritance, and Complex Traits / Selected Genetically Engineered Models Relevant to Human Neurodegenerative Disease / Gene Mapping to Gene Targeting:: Application of Mouse Genetics to Human Disease / Human Genomics and Disease / Gene Therapy for Central Nervous System Disorders / Emerging Ethical Issues in Neurology, Psychiatry, and the Neurosciences / Genotype-Phenotype Correlations
NEUROLOGIC DISEASES:: Down Syndrome / Triplet Repeat Diseases:: Genetics, Clinical Features, and Pathogenesis / Prion Diseases
Mitochondrial Disorders:: The Mitochondrial Genome / Mitochondrial Disorders Due to Mutations in the Mitochondrial Genome / Mitochondrial Disorders Due to Mutations in the Nuclear Genome / Mitochondria in Neurodegenerative Disorders
Peroxisomal Disorders:: Perioxisomal Disorders
Lysosomal Disorders:: Gaucher Disease / The Niemann-Pick Diseases / The Gm2-Gangliosidoses / Metachromatic Leukodystrophy and Multiple Sulfatase Deficiency:: Sulfatide Lipidosis / Krabbe Disease:: Globoid Cell Leukodystrophy / The Mucopolysaccharidoses and the Mucolipidoses / Disorders of Glycoprotein Degradation:: Sialidosis, Fucosidosis, Alpha-Mannosidosis, Beta- / Beta-Galactosidase Deficiency:: GM1 Gangliosidosis, Morquio B Disease, and Galactosialidosis / Farber Disease:: Acid Ceramidase Deficiency, Farber Lipogranulomatosis / Wolman Disease / Lysosomal Membrane Disorders:: LAMP-2 Deficiency / Fabry Disease:: Alpha Galactosidase A Deficiency / Schindler Disease:: Deficient Alpha-N-Acetylgalacosaminidase Activity
Degenerative Disorders:: Alzheimers Disease / Frontotemporal Dementias / Genetics of Movement Disorders / The Inherited Ataxias / Canavan Disease / Hereditary Spastic Paraplegia
Neuro-Oncology:: Neuro-Oncology:: The Neurofibromatoses
Epilepsy:: The Genetic Epilepsies
Demyelinating Disease:: Demyelinating Diseases
Neuropathies and Neuronopathies:: Peripheral Neuropathies / The Molecular and Genetic Basis of Spinal Muscular Atrophies
Congenital Myasthenic Syndromes:: Congenital Myasthenic Syndromes
Myopathies:: Dystrophinopathies / Limb-Girdle Muscular Dystrophies / The Congenital Myopathies / The Distal Myopathies / Hereditary Inclusion-Body Myopathies / The Myotonic Dystrophies / Facioscapulohumeral Dystrophy / Ion Channel Disorders
Dermatologic and Brain Disorders:: The Phakomatoses / Lipoprotein Disorders / Apolipoprotein E:: Structure and Function in Lipid Metabolism and Neurobiology / Cerebrotendinous Xanthomatosis
Metabolic Disorders:: Disorders of Lipid Metabolism / Glycogen Storage Diseases / Disorders of Galactose Metabolism / Inborn Errors of Amino Acid Metabolism / Disorders of the Urea Cycle / Disorders of Glucose Transport / Maple Syrup Urine Disease:: Clinical and Biochemical Perspectives / Congenital Disorders of N-linked Glycosylation / Disorders of Glutathione Metabolism
Purines:: Purines
Porphyrias:: The Porphyrias
Metal Metabolism:: Friedreich Ataxia / Disorders of Copper Metabolism:: Wilson Disease and Menkes Disease
Vitamins:: Genetic and Dietary Influences on Life Span / Vitamins:: Cobalamin and Folate / Disorders of Biotin Metabolism:: Treatable Neurologic Syndromes
PSYCHIATRIC DISEASE:: Psychiatric Diseases:: Challenges in Psychiatric Genetics / Depression / Bipolar Disorder / Schizophrenia / Obsessive-Compulsive Disorder and Tourettes Syndrome / Genetic Bases of Addictive Behaviors / Autism
A NEUROLOGIC GENE MAP:: A Neurologic Gene Map
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