In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes.
Introduction to the Thalassemia Syndromes: Molecular Medicines Index Case The Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation Perspective Molecular Basis and Genetic Modifiers of Thalassemia Fetal Hemoglobin Regulation in Beta-Thalassemia Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia The Clinical Phenotypes of Alpha Thalassemia Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability Pathogenic Mechanisms in Thalassemia II: Iron Overload Clinical Complications and Their Management Clinical Challenges with Iron Chelation in Beta Thalassemia Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia Hematopoietic Stem Cell Transplantation in Thalassemia Gene Therapy and Gene Editing for b-Thalassemia Emerging Therapies in b-Thalassemia
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