In this issue of Clinics in Liver Disease, guest editors Drs. Ira M. Jacobson and AnnMarie Liapakis bring their considerable expertise to the topic of The Liver in Systemic Disease. Top experts in hepatology provide important clinical updates on this important topic, including telomere disorders and the liver; bacterial infections involving the liver; inborn errors of metabolism and the liver; the liver in diabetes and metabolic syndrome; autoimmune disease and the liver; and more.