Together with Consulting Editor, Dr. Charles Lightdale, Dr. Doug Rex has put together an issue of Gastrointestinal Endoscopy Clinics that provides state-of-the-art clinical coverage of colorectal screening. Expert authors from all over the world have contributed clinical reviews that will be a staple for all practicing endoscopists. The articles are devoted to the following topics:: What is organized screening and what is its value; Screening decisions in the opportunistic setting; The National Colorectal Cancer Round Table:: Past performance and current and future goals; Proven strategies for increasing screening adherence; Colorectal cancer in persons under age 50:: Seeking causes and solutions; Risk stratification strategies:: From logistic regression to artificial intelligence; Cost-effectiveness of current screening tests; Quality in colorectal cancer screening; Screening for the serrated pathway; FIT:: The worlds colorectal cancer screening test; Fecal DNA testing:: What has it accomplished and where is it headed; Is bowel preparation without complete colon clearing a viable concept:: Update on flexible sigmoidoscopy, CTC, and capsule colonoscopy; Evidenced based screening strategies for a positive family history; Aspirational ADR and ideal colonoscopy performance:: How long can we go between colonoscopies; and How Artificial Intelligence will impact colonoscopy and colorectal cancer screening. Readers will come away with the clinical knowledge they need to improve outcomes in colon cancer screening and prevention.