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Pathology of Genetically Engineered and Other Mutant Mice

Pathology of Genetically Engineered and Other Mutant Mice

9781119624578
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Description

An updated and comprehensive reference to pathology in every organ system in genetically modified mice

The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.

The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.

Readers will also benefit from::

  • A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice
  • An exploration of concepts related to validating animal models, including the Cinderella Effect
  • Practical discussions of basic necropsy methods and grading lesions for computational analyses
  • Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues

As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Product Details
Wiley-Blackwell
101392
9781119624578

Data sheet

Publication date
2022
Issue number
1
Cover
hard cover
Pages count
560
Dimensions (mm)
225.00 x 279.00

  • List of Contributors vii

    Preface and Acknowledgments x

    1 Introduction to Mouse Pathology 1
    Jerrold M. Ward, Peter Vogel, and John P. Sundberg

    2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research 6
    Dale A. Begley, Paul N. Schofield, and John P. Sundberg

    3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics 22
    John P. Sundberg, Dale A. Begley, Melissa L. Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield

    4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect 39
    John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofield

    5 Embryos, Placentas, and Neonates 48
    Brad Bolon and Jerrold M. Ward

    6 Ciliopathies 72
    Peter Vogel and Laura J. Janke

    7 Hematopoietic and Lymphoid Tissues 82
    Harm HogenEsch and John P. Sundberg

    8 Mouse Hematolymphoid Neoplasms 97
    Jerold E. Rehg

    9 Immunodeficient and Humanized Mice 132
    Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch

    10 Skin, Hair, and Nails 159
    John P. Sundberg, Lloyd E. King, Jr, and Raoul V. Kuiper

    11 Mammary Gland 213
    Alexander D. Borowsky and Robert D. Cardiff

    12 The Respiratory Tract 237
    Jerrold M. Ward and John P. Sundberg

    13 The Gastrointestinal Tract 259
    Jerrold M. Ward, Piper M. Treuting, and M. Kay Washington

    14 Cardiovascular System 284
    Kathleen L. Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy K. Cooper

    15 Liver and Pancreas 307
    Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger

    16 Neuromuscular System 336
    Peter Vogel, Laura J. Janke, and Heather W. Sheppard

    17 Endocrine System 355
    Krista M. D. La Perle

    18 Kidney and Urinary Bladder 378
    Jeffrey B. Kopp, Avi Z. Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, and Jerrold M. Ward

    19 Female Reproductive System 403
    Darlene Dixon and Alexander Yu. Nikitin (In Memory of Dr. Joel Mahler)

    20 Male Reproductive System 431
    Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, and Robert D. Cardiff

    21 Nervous System 462
    Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli

    22 Eye and Ear 493
    Heather W. Sheppard, Laura J. Janke, Jerold E. Rehg, and Peter Vogel

    23 Bones and Teeth 520
    Peter Vogel, John P. Sundberg, and Cheryl Ackert-Bicknell

    Index 541

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