Veterinary Pharmacology and Therapeutics

Contributors xiii

Preface xix

About the Companion Website xxi

Section 1 Principles of Pharmacology 1

1 Veterinary Pharmacology:: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich

2 Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere

3 Pharmacokinetics 41
Jim E. Riviere

4 Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain

5 Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez

Section 2 Drugs Acting on the Autonomic Nervous System 111

6 Introduction to the Autonomic Nervous System and Autonomic Pharmacology 113
Joshua A. Rowe, Rose M. McMurphy, Barbara J. Lutjemeier, and Michael J. Kenney

7 Adrenergic Receptor Agonists and Antagonists 131
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and ;Michael J. Kenney

8 Cholinergic Pharmacology:: Autonomic Drugs 151
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Marjory A. Artzer, Barbara J. Lutjemeier, and Michael J. Kenney

Section 3 Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165

9 Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey

10 Neuromuscular Blocking Agents 194
Diane E .Mason and Christopher L. Norkus

11 Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey

12 Injectable Anesthetic Agents 247
Lysa P. Posner

13 Opioid Analgesic Drugs 281
Butch KuKanich and Mark G. Papich

14 Sedatives and Tranquilizers 324
Lysa P. Posner

15 Local Anesthetics 369
Thomas W. Vickroy

16 Euthanizing Agents 387
Anna Hampton

17 Anticonvulsant Drugs 395
Mark G. Papich

18 Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

Section 4 Autacoids and Antiinflammatory Drugs 449

19 Histamine, Serotonin, and their Antagonists 451
Wolfgang Baumer

20 Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees

Section 5 Drugs Acting on the Cardiovascular System 501

21 Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames

22 Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere

Section 6 Drugs Affecting Renal Function and Fluid–Electrolyte Balance 553

23 Principles of Acid–Base Balance:: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

24 Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar

Section 7 Drugs Acting on Blood and Blood Elements 623

25 Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich

Section 8 Endocrine Pharmacology 647

26 Hypothalamic and Pituitary Hormones 649
Srujana Rayalam, Margarethe Hoenig, and Duncan C. Ferguson

27 Hormones Affecting Reproduction 674
Wolfgang Baumer, C. Scott Bailey, and John Gadsby

28 Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson

29 Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
Duncan C. Ferguson and Margarethe Hoenig

30 Drugs Influencing Glucose Metabolism 763
Margarethe Hoenig

Section 9 Chemotherapy of Microbial Diseases 779

31 Antiseptics and Disinfectants 781
Megan E. Jacob

32 Sulfonamides and Potentiated Sulfonamides 796
Mark G. Papich

33 ß-Lactam Antibiotics:: Penicillins, Cephalosporins, and Related Drugs 826
Mark G. Papich

34 Tetracycline Antibiotics 858
Mark G. Papich and Jim E. Riviere

35 Aminoglycoside Antibiotics 877
Mark G. Papich and Jim E. Riviere

36 Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 903
Mark G. Papich

37 Fluoroquinolone Antimicrobial Drugs 953
Mark G. Papich

38 Antifungal and Antiviral Drugs 988
Jennifer L. Davis and Lara Maxwell

Section 10 Chemotherapy of Parasitic Diseases 1033

39 Antinematodal Drugs 1035
Carlos E. Lanusse, Juan M. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez

40 Anticestodal and Antitrematodal Drugs 1081
Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel

41 Macrocyclic Lactones:: Endectocide Compounds 1102
Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz

42 Antiprotozoan Drugs 1128
Jennifer L. Davis and Jody L. Gookin

43 Ectoparasiticides 1166
Ronald E. Baynes

Section 11 Specialty Areas of Pharmacology 1189

44 Chemotherapy of Neoplastic Diseases 1191
Luke A.Wittenburg and Daniel L. Gustafson

45 Immunosuppressive Drugs 1226
Mark G. Papich

46 Drugs for Treating Gastrointestinal Diseases 1245
Mark G. Papich

47 Dermatopharmacology:: Drugs Acting Locally on the Skin 1278
Jim E. Riviere and Rosanna Marsella

48 Drugs that Affect the Respiratory System 1302
Mark G. Papich

49 Ophthalmic Pharmacology 1321
Alison Clode

50 Pharmacogenomics 1332
Katrina L. Mealey

51 Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1345
Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring

52 Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
Michael D. Apley

53 Pharmacology in Aquatic Animals 1373
Ron A. Miller

54 Zoological Pharmacology 1395
Robert P. Hunter

Section 12 Regulatory and Other Considerations 1405

55 The Regulation of Animal Drugs 1407
Steven D. Vaughn and Marilyn N. Martinez

56 Veterinary Pharmacy 1427
Gigi Davidson and Mark G. Papich

57 Medication Control Programs in Performance Animals 1439
Cynthia A. Cole

58 Pharmacovigilance 1448
John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer

59 Dosage Forms and Veterinary Feed Directives 1459
Geof Smith and Jim E. Riviere

60 Evidence-Based Pharmacotherapy 1465
Ronette Gehring

61 Chemical Residues in Tissues of Food Animals 1469
Jim E. Riviere

Index 1481