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Goldfrank's Toxicologic Emergencies, Eleventh Edition

Goldfrank's Toxicologic Emergencies, Eleventh Edition

9781259859618
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Description
The best edition yet of the landmark text in medical toxicology

Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins. 

Fully referenced and supported by a cohesive organization and full-color format, Goldfranks begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations. 

The Eleventh Edition of Goldfranks Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis. 

New to this Edition:: 
•Additional cases and “Special Considerations” chapters designed to enhance clinical decision-making and patient outcomes
•New “Antidotes in Depth” provides timely, critical information on toxicologic treatment strategies 
•New content on toxicogenomics explores its increasingly important role in predictive toxicology
•Chapter-ending bulleted summaries of key points  
•Updated coverage of synthetics such as “K2” 
•Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools


Product Details
McGraw Hill / Medical
60708
9781259859618
9781259859618

Data sheet

Publication date
2019
Issue number
11
Cover
hard cover
Dimensions (mm)
226 x 282
Weight (g)
4312

  • 1.                Historical Principles and Perspectives

              Paul M. Wax

     

    2.                Toxicologic Misfortunes and Catastrophes in History

              Paul M. Wax

     

    PART A

    THE GENERAL APPROACH TO THE PATIENT

     

    3.                Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes

              Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman

     

    4.                Principles of Managing the Acutely Poisoned or Overdosed Patient

              Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions]

     

    SC1.    Principles of Antidote Stocking

              [Insert author(s)]

     

    5.                Decontamination Principles: Prevention of Gastrointestinal Absorption

              Lotte C. G. Hoegberg and Anne-Bolette Gude

     

    SC2.    Decontamination Principles: Prevention of Dermal, Inhalational and Ocular    Absorption

              [Insert author(s)]

     

    A1.      Activated Charcoal

              Silas W. Smith and Mary Ann Howland

     

        A2.      Whole-Bowel Irrigation and Other Intestinal Evacuants

              Silas W. Smith and Mary Ann Howland

     

    6.                Principles and Techniques Applied to Enhance Elimination

              David S. Goldfarb and Marc Ghannoum

     

    7.                Laboratory Principles

              Petrie M. Rainey

     

    8.                Principles of Diagnostic Imaging

              David T. Schwartz

     

    9.                Pharmacokinetic and Toxicokinetic Principles

              Mary Ann Howland

     

     

    PART B

    THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY

     

         SECTION I

       BIOCHEMICAL AND MOLECULAR CONCEPTS

     

    10.            Chemical Principles

              Stephen J. Traub and Lewis S. Nelson

     

    11.            Biochemical and Metabolic Principles

              Kurt C. Kleinschmidt and Kathleen A. Delaney

     

    12.            Fluid, Electrolyte, and Acid–Base Principles

              Alan N. Charney and Robert S. Hoffman

     

    13.            Neurotransmitters and Neuromodulators

              Steven C. Curry, Ayrn D. OConnor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik

     

    14.            Withdrawal Principles

              Richard J. Hamilton and [new author]

     

    SECTION II

    PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS

     

    15.            Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles

              Cathleen Clancy

     

    16.            Cardiologic Principles II: Hemodynamics

    [new author] and Robert A. Hessler

     

    17.            Dermatologic Principles

              Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson

     

         SC3.    Transdermal Toxicology

    Lewis S. Nelson

     

    18.            Gastrointestinal Principles

              Matthew D. Zuckerman and Richard J. Church

     

    19.            Genitourinary Principles

              Jason Chu

     

    20.            Hematologic Principles

              Marco L.A. Sivilotti

     

     

    21.            Hepatic Principles

              Kathleen A. Delaney

     

    22.            Neurologic Principles

              Rama B. Rao

     

    23.            Oncologic Principles

    Richard Wang

     

    24.            Ophthalmic Principles

              Adhi Sharma

     

    25.            Otolaryngologic Principles

    [new author] and William Chiang

     

    26.            Psychiatric Principles

              Erin A. Zerbo and Andrea M. Kondracke

     

    27.            Renal Principles

              Marc Ghannoum and David S. Goldfarb

     

    28.            Respiratory Principles

              Andrew Stolbach and Robert S. Hoffman

     

    29.            Thermoregulatory Principles

              Susi U. Vassallo and Kathleen A. Delaney

     

    SECTION III

    SPECIAL POPULATIONS

     

    30.            Reproductive and Perinatal Principles

              Jeffrey S. Fine

     

    31.            Pediatric Principles

              Jeffrey S. Fine

     

    32.            Geriatric Principles

              Judith C. Ahronheim and Mary Ann Howland

     

    PART C

    THE CLINICAL BASIS OF MEDICAL TOXICOLOGY

     

    SECTION I

    A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS

     

    Case Study 1

     

    33.            Acetaminophen

              Robert G. Hendrickson

     

        A3.      N-Acetylcysteine

               Robert G. Hendrickson and Mary Ann Howland

     

    34.            Colchicine, Podophyllin, and the Vinca Alkaloids

              Joshua G. Schier

     

    35.            Nonsteroidal Antiinflammatory Drugs

              William J. Holubek

     

    36.            Opioids

              Lewis S. Nelson and Dean Olsen

     

         A4.      opioid antagonists

              Lewis S. Nelson and Mary Ann Howland

     

    SC4.    Internal Concealment of Xenobiotics

              Jane M. Prosser

     

    SC5.    Harm Reduction for Opioid Overdose

              ?Josh Lee

     

    37.            Salicylates

              Daniel M. Lugassy

     

    A5.      sodium bicarbonate

    Paul M. Wax

     

     

    B. Food, Diet, and Nutrition

     

    CASE STUDY 2

     

    38.            Botulism

              Howard L. Geyer

     

    A6.      botulinum antitoxin

              Silas W. Smith and Howard L. Geyer

     

    39.          Food Poisoning

    [new author]and Michael Tunik

     

    40.            Dieting Xenobiotics and Regimens

              Jeanna M. Marraffa

     

    41.            Athletic Performance Enhancers

    Susi U. Vassallo

     

    42.            Essential Oils

    Lauren Kornreich Shawn

     

    43.            Herbal Preparations

    [new author] and Oliver Hung

     

    44.          Vitamins

              Beth Y. Ginsburg

     

    45.            Iron

              Jeanmarie Perrone

     

         A7.      deferoxamine

    Mary Ann Howland

     

    C. pharmaceuticals

     

    case study 3

     

    46.            Pharmaceutical Additives

    Sean P. Nordt and Lisa E. Vivero

     

    47.            Antidiabetics and Hypoglycemics/Antiglycemics

              George M. Bosse

     

    A8.      Dextrose (d-Glucose)

    [new author] and Larissa Velez

     

    A9.      octreotide

              Mary Ann Howland and Silas W. Smith

     

    48.            Antiepileptics

              Suzanne Doyon

     

    A10.    l-carnitine

              Mary Ann Howland

     

    49.            Antihistamines and Decongestants

              Sophie Gosselin

     

    A11.    physostigmine salicylate

              Mary Ann Howland

     

    50.            Chemotherapeutics

              Richard Y. Wang

     

    51.            Methotrexate, 5-Flourouracil, and Capecitabine         

    Richard Y. Wang

     

    A12.    folates: leucovorin (Folinic acid) and Folic Acid

              Mary Ann Howland

     

    A13.    glucarpidase (carboxypeptidase g2)

              Silas W. Smith

     

    A14.    uridine triacetate

              Silas W. Smith

     

    SC6.    Inadvertent Intrathecal Administration of Xenobiotics

              Rama B. Rao

     

    SC7.    Extravasation of Chemotherapeutics

    Richard Y. Wang

     

    52.            Antimigraine Medications

    Jason Chu

     

    53.            Thyroid and Antithyroid Medications

              Nicole C. Bouchard

     

    D. Antimicrobials

     

    54.            Antibacterials, Antifungals, and Antivirals

    Christine M. Stork

     

    55.            Antimalarials

              James David Barry

     

    56.            Antituberculous Medications

              Christina H. Hernon

     

         A15.    pyridoxine

              Mary Ann Howland

     

    E. Cardiopulmonary Medications

     

    CASE STUDY 4

     

    57.            Antidysrhythmics

              Lewis S. Nelson

     

    A16.    Magnesium Sulfate

              Silas Smith

     

    58.            Antithrombotics

              Betty C. Chen and Mark Su

     

    A17.    Protein Complex Concentrate and novel Antithrombotic Antidotes

              [Insert author(s)], Betty Chen and Mark Su

     

    A18.    Vitamin k1

              Mary Ann Howland

     

    A19.    protamine

    Mary Ann Howland

     

    59.            ß-Adrenergic Antagonists

              Jeffrey R. Brubacher

     

    A20.    Glucagon

              Mary Ann Howland

     

    60.            Calcium Channel Blockers

              David H. Jang and Francis Jerome DeRoos

     

    A21.    High-dose insulin euglycemia

              Samuel J. Stellpflug and William Kerns, II

     

    61.            Miscellaneous Antihypertensives and Pharmacologically Related Agents

    Francis Jerome DeRoos

     

    62.            Cardioactive Steroids

              Jason B. Hack

     

    A22.    digoxin-specific antibody fragments

              Mary Ann Howland

     

    63.            Methylxanthines and Selective ß2-Adrenergic Agonists

              Robert J. Hoffman

     

     

    F. ANESTHETICS AND RELATED MEDICATIONS

     

    64.            Local Anesthetics

              David R. Schwartz and Brian Kaufman

     

    A23.    intravenous lipid emulsion

              [new author] and Todd Bania

     

    65.            Inhalational Anesthetics

              Brian Kaufman

     

    66.            Neuromuscular Blockers

              Kenneth M. Sutin

     

    A24.    dantrolene sodium

    Kenneth M. Sutin

     

    A25.    Sugammadex

    [new; Author]

     

    G. Psychotropics

     

    CASE STUDY 5

     

    67.            Antipsychotics

              David Juurlink

     

    68.            Cyclic Antidepressants

              Erica L. Liebelt

     

    69.            Serotonin Reuptake Inhibitors and Atypical Antidepressants

              Christine M. Stork

     

    70.            Lithium

              Howard A. Greller

     

    71.            Monoamine Oxidase Inhibitors

              Alex F. Manini

     

    72.            Sedative-Hypnotics

              David C. Lee

     

    A26.    flumazenil

              Mary Ann Howland

     

    H. SUBSTANCES OF ABUSE

     

    CASE STUDY 6

     

    73.            Amphetamines

              David H. Jang

     

    74.            Cannabinoids

              Jeff M. Lapoint

     

    75.            Cocaine

              Jane M. Prosser and Robert S. Hoffman

     

    A27.     Benzodiazepines

              Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland

     

    76.            Ethanol

              Luke Yip

     

    A28.    Thiamine hydrochloride

              Robert S. Hoffman

     

    77.            Ethanol Withdrawal

              Jeffrey A. Gold and Lewis S. Nelson

     

    78.            Disulfiram and Disulfiram-like Reactions

              Amit K. Gupta

     

    79.            <

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