In this issue of Surgical Oncology Clinics, guest editor Dr. Jason K. Sicklick brings his considerable expertise to the topic of Precision Medicine and Cancer Surgery. Top experts in the field discuss specific surgical areas of precision oncology, such as breast cancer, lung cancer, colorectal cancer, melanoma, and sarcoma, as well as related topics such as immune-oncology, histology, molecular testing, biologics, and targeted therapies.