This 7th Edition continues to be the most definitive, comprehensive, and well-referenced resource to consult in Rheumatology. for important facts and analyses of all basic and clinical science in the field of rheumatology. Covering both basic and clinical science, the text provides authoritative and encyclopedic coverage of not only the aetiology and pathogenesis of the rheumatic diseases, but also of biology of the normal joint, immune and inflammatory responses, evaluation of the patient, musculoskeletal pain and the musculoskeletal exam, diagnostic tests and procedures, clinical pharmacology and much more.
Section I: Structure and Function of Bone, Joints, and Connective Tissue
1. Biology of the Normal Joint 2. Collagen and Elastin 3. Matrix Glycoproteins and Proteoglycans in Cartilage 4. Proteinases and Matrix Degradation 5. Muscle: Anatomy, Physiology, and Chemistry 6. Biomechanics of Joints
Section II: Cells Involved in Autoimmune Diseases and Inflammation
7. Antigen Presenting Cells 8. Innate Immunity 9. T Lymphocytes 10. B Cells 11. Synoviocytes 12. Fibroblast Function and Fibrosis 13. Chondrocytes 14. Neutrophils and Eosinophils 15. Platelets and Rheumatic Diseases
Section III: Effector mechanisms in Autoimmunity and Inflammation
16. Autoimmunity 17. Genetics of Rheumatic Diseases 18. Signal Transduction in Rheumatic Diseases 19. Rheumatoid Factor 20. Antinuclear Antibodies 21. Immune Complexes 22. Complement System 23. Prostaglandins, Leukotrienes, and Related Compounds 24. Recruitment of Cells and Angiogenesis 25. Cytokines 26. Apoptosis
Section IV: Broad Issues in the Approach to Rheumatic Diseases
27. Epidemiology of the Rheumatic Diseases 28. Economic Burden of Rheumatic Diseases 29. Assessment of Health Outcomes 30. Development, Execution, and Analysis of Clinical Trials 31. Occupational and Recreational Musculoskeletal Disorders 32. Alternative Care for Arthritis and Related Musculoskeletal Diseases
Section V: Evaluation of Generalized and Localized Symptoms
33. History and Physical Examination of the Musculoskeletal System 34. Monarticular Arthritis 35. Polyarticular Arthritis 36. Fibromyalgia: A Chronic Pain Syndrome 37. Neck Pain 38. Shoulder Pain 39. Low Back Pain 40. Hip and Knee Pain 41. Ankle and Foot Pain 42. Hand and Wrist Pain 43. Temporomandibular Joint Pain 44. The Eye and Rheumatic Disease 45. The Skin and Rheumatic Diseases
Section VI: Diagnostic Tests and Procedures in Rheumatic Diseases
46. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology 47. Arthrocentesis and Injection of Joints and Soft Tissues 48. Arthroscopy 49. Laboratory Evaluation of Inflammatio 50. Biological Markers 51. Imaging of Bones, Joints, and Connective Tissue
Section VII: Modalities of Therapy in Rheumatic Diseases: Non-pharmacologic Interventions
52. Education of Patients 53. Psychosocial Management of the Rheumatic Diseases 54. Nutrition and Rheumatic Diseases 55. Rehabilitation of Patients with Rheumatic Diseases
Section VIII: Drug Therapy for Rheumatic Diseases
56. Nonsteroidal Anti-inflammatory Drugs 57. Glucocorticoid Therapy 58. Second-line Agents: Sulfasalazine, Anti-malarials, Gold Salts, and D-penicillamine 59. Methotrexate, Leflunomide, and Combination Therapies 60. Immunoregulatory Drugs 61. Anti-cytokine Therapies 62. Emerging Therapies 63. Pharmacology and the Elderly 64. Chronic Musculoskeletal Pain
VOLUME 2
Section IX: Rheumatoid Arthritis
65. Etiology and Pathogenesis of Rheumatoid Arthritis 66. Clinical Features of Rheumatoid Arthritis 67. Treatment of Rheumatoid Arthritis 68. Feltys Syndrome 69. Sjogrens Syndrome
Section XI: Systemic Lupus Erythematosus and Related Syndromes
74. Pathogenesis of SLE 75. Clinical Manifestations of Systemic Lupus Erythematosus 76. Management of Systemic Lupus Erythematosus 77. Antiphospholipid Antibody Syndrome
Section XII: Mixed Connective Tissue Disease, Scleroderma, and Inflammatory Myopathies
78. Mixed Connective Tissue Disease and Other Overlap Syndromes 79. Scleroderma and Raynauds Disease 80. Inflammatory Diseases of Muscle and Other Myopathies
Section XIII: Vasculitis
81. The Classification and Epidemiology of Systemic Vasculitis 82. Giant Cell Arteritis, and Polymyalgia Rheumatica, 83. Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis: Wegeners Granulomatosis, Microscopic Polyangitis and Churg Strauss Syndrome 84. Polyarteritis and Related Disorders 85. Cutaneous Small-Vessel Vasculitis 86. Behcets Disease
Section XIV: Crystal-induced Inflammation
87. Gout and Hyperuricemia 88. Diseases Associated with Articular Deposition of Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate Crystals
Section XV: Bone, Cartilage, and Heritable Connective Tissue Disorders
89. Biology, Physiology, and Morphology of Bone 90. Metabolic Bone Disease 91. Pathogenesis of Osteoarthritis 92. Clinical Features of Osteoarthritis 93. Management of Osteoarthritis 94. Relapsing Polychondritis 95. Heritable Disorders of Structural Proteins
98. Arthritis Caused by Bacteria or Their Components 99. Lyme Disease 100. Mycobacterial and Fungal Infections 101. Rheumatic Manifestations of Human Immunodeficiency Virus Infection 102. Viral Arthritis 103. Acute Rheumatic Fever and Post-Streptoccocal Arthritis
XVIII: Arthritis Accompanying Systemic Diseases
104. Amyloidosis 105. Sarcoidosis 106. Iron Storage Disease 107. Hemophilic Arthropathy 108. Hemoglobinopathies and Arthritis 109. Arthritis Accompanying Endocrine and Metabolic Disorders 110. Hypertrophic Osteoarthropathy 111. Musculoskeletal Syndromes in Malignancy 112. Familial Auto-inflammatory Syndromes
XIX: The Common Ground of Rheumatology and Orthopaedic Surgery
113. Tumors and Tumor-like Lesions of Joints 114. Osteonecrosis 115. Introduction to Surgical Management of Patients with Arthritis 116. Principles of Reconstructive Surgery for Arthritis