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Essential Concepts in Clinical Research

Essential Concepts in Clinical Research

Randomised Controlled Trials and Observational Epidemiology

9780702073946
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Description

This practical guide speaks to two audiences:: those who read and those who conduct research. Clinicians are medical detectives by training. For each patient, they assemble clinical clues to establish causes of signs and symptoms. The task involves both clinical acumen and knowledge of medical research. This book helps guide clinicians through this detective work, by enabling them to make sense of research and to review medical literature critically. It will also be invaluable to researchers who conduct clinical research, particularly randomized controlled trials.

Building on previously published, peer-reviewed articles from The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods.

Product Details
Elsevier
60219
9780702073946
9780702073946

Data sheet

Publication date
2018
Issue number
2
Cover
paperback
Pages count
272
Dimensions (mm)
152 x 229
Weight (g)
400

  • Introduction

    1. An overview of clinical research: the lay of the land

    Observational studies

    2. Descriptive studies: what they can and cannot do

    3. Bias and causal associations in observational research

    4. Cohort studies: marching towards outcomes

    5. Case-control studies: research in reverse

    6. Finding controls for case-control studies: compared to what?

    7. Limitations of observational epidemiology

    Screening tests

    8. Uses and abuses of screening tests

    9. Refining clinical diagnosis with likelihood ratios

    Randomized controlled trials

    10. Boosting participant recruitment in trials

    11. Sample size calculations in randomized trials: mandatory and mystical

    12. Generation of allocation sequences in randomized trials: chance not choice

    13. Generation of allocation sequences in non-double-blinded randomized trials: guarding against guessing

    14. Allocation concealment in randomized trials: defending against deciphering

    15. Exclusions and losses in randomized trials: sample size slippages

    16. Blinding in randomized trials: hiding who got what

    17. Implementing treatment blinding in randomized trials

    18. Surrogate endpoints and composite outcomes: shortcuts to unknown destinations

    19. Multiplicity in randomized trials I: endpoints and treatments

    20. Multiplicity in randomized trials II: subgroup and interim analyses

    21. Conducting randomized trials as part of a prospective meta-analysis

    Publishing

    22. Reporting studies in medical journals: CONSORT and other guidelines

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