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Quantitation in Biomedical Imaging with PET and MRI

Proceedings of the International workshop on Quantitation in Biomedical Imaging with PET and MRI held in Osaka, Japan, between 26 and 27 January 2004, ICS 1265

9780444515674
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Description
Quantitation in Biomedical Imaging with PET and MRI is a selection of invited papers presented at the International Workshop on Quantitation in Biomedical Imaging with PET and MRI, held in Osaka, Japan. Leading experts from around the world were invited, along with one hundred and fourteen physicians, technicians, and scientists who are involved in PET and MRI as well as drug development to give an overview of the recent progresses that have been made in the methodology of quantitative assessment of biomedical images in the brain using PET and MRI.

PET and MRI are rapidly emerging technologies that provide three-dimensional images, which reflect biological and physiological processes in vivo. Quantitation in Biomedical Imaging with PET and MRI overviews recent advances in PET/MRI devices and in image processing algorithms and their applications in clinical studies. Potentials for absolute quantitation of physiologic parameters with MRI and the use of hyperpolarized xenon as a new contrast agent in MRI have also been addressed. The role and importance of the methodological advances have been further discussed to understand the vascular controlling mechanism during neuronal activation, and the patho-physiology in brain diseases.

This book has been published to share the ideas of valuable discussions introduced in the workshop. Divided into three chapters, which include PET basics, MRI basics and the application of PET and MRI techniques, Quantitation in Biomedical Imaging with PET and MRI will be a useful tool to those interested in the basics of quantitative molecular imaging, both with PET and MRI.
Product Details
Bailliere Tindall
48020
9780444515674
9780444515674

Data sheet

Publication date
2004
Issue number
1
Cover
hard cover
Pages count
296
Dimensions (mm)
165 x 240
Weight (g)
635
  • Preface.

    Quantitation in PET and image processing.

    Invited lecture. Role of human and animal PET studies in drug development (A.A. Lammertsma). Kinetic analysis of neuroreceptor binding using PET (V.J. Cunningham). Session. Formation of parametric image with statistical clustering (Y. Kimura). Development of motion correction technique for PET study using optical tracking system (H. Watabe). 3D deformable image processing and integration (K.-P. Lin). Impact of inter-subject image registration on group analysis of fMRI data (B.. Ardekani et al.). Rapid protocol for quantitative CMRO2 and CBF using PET and O-15 labelled compounds (N. Kudomi). Poster. Performance evaluation of microPET P4 for rat, rabbit and monkey (Y. Wada et al.). Simultaneous quantification of two brain functions with dual tracer injection in PET dynamic study (Y. Ikoma). Improved parametric images of blood flow and vascular volume by cluster analysis in H215O brain PET study (K.M. Kim). Impact of image-based scatter correction for 123IMP-SPECT and SPM analysis (M. Shidahara). Development of FDG-PET quantitative procedures without blood sampling (L.-C. Wu). New method for the synthesis of [15O]CO and [15O]CO2 for rapid supply in clinical use (Y. Miyake). Neutron reduction of the small cyclotron for production of oxygen-15 labeled gases (T. Inomata et al.). Image improvement in pinhole spect using complete data acquisition combined with statistical image reconstruction (T. Zeniya). The effect of motion correction on quantification of myocardial blood flow in 15O-H2O PET study (K. Koshino).

    Quantitation and hyperpolarized contrast agent in MRI.

    Invited lecture. Quantitative T1 mapping and absolute water content measurement using MRI (H. Neeb, T. Dierkes, N.J. Shah). Session. Hyperpolarized Xe-129 as a pulmonary contrast agent in MRI: experimental results with mice at 9.4T (H. Fujiwara). Dynamic spectroscopy of hyperpolarized Xe-129 in rat lung (H. Sato). In vivo MR spectroscopy of hyperpolarized Xe-129 in rat brain (A. Wakai et al.). Developments of apparatus for hyperpolarization of Xe-129: optimized structure of cell for efficient spin exchange at a high concentration of optically pumped rubidium (M. Hattori). Measurement of cerebral blood flow with dynamic susceptibility contrast MRI and comparison with O-15 positron emission tomography (J. Enmi et al.). Measurement of cerebral circulation by dynamic susceptibility contrast MRI: effect of tracer delay (M. Ibaraki). Poster. MRI and MRS of mouse head at 9.4T using hyperpolarized xenon gas (T. Wakayama). Practical application of NMR spectra of 129Xe dissolved in RBC temperature dependence and magnetization transfer (Y. Kawata). MRI and MRS of hyperpolarized 129Xe in the chest of mouse. Effect of contrast agents on the MRS (M. Narazaki). Distortion correction in echo planar imaging, and quantitative T2* mapping (T. Dierkes, H. Neeb, N.J. Shah).

    Application of quantitative PET and MRI techniques.

    Invited lecture. Quantitative PET for assessment of cerebral blood flow and glucose consumption under varying physiological conditions (G. Knudsen). Cortical layer-dependent CBF changes induced by neural activity (S-G. Kim, S-P. Lee). Session. Changes in CBF and CBV during changes in neural activity or PaCO2 measured by PET (H. Ito et al.). Measurement of arterial part of vascular volume (V0) for evaluation of hemodynamic changes in cerebrovascular disease (H. Okazawa). The relationship of cerebral oxygen delivery and metabolism evaluated by effective oxygen diffusibility (EOD) using PET (T. Hayashi). Cerebral perfusion measurements using continuous arterial spin labeling (CASL): accuracy and limits of quantitative approach (H. Kimura). Positron emission tomography - molecular imaging of biological processes (J. Knuuti). Poster. Absolute quantification of regional cerebral glucose utilization in awake and anesthetized mice by [18F]FDG/small animal PET scanning and 2-[14C]DG autoradiography (H. Toyama). Development of injectable O-15 oxygen and its application for estimation of OEF (T. Temma). Imaging of vulnerable atherosclerotic plaque with [18F]FDG-PET: an animal atherosclerosis model study (M. Ogawa et al.). Development of modified method for quantification of regional myocardial blood flow using 15O-water with PET (C. Katoh). Using probability maps for automatic extraction of quantitative volume of interest (VOI) values from human brain images (C. Svarer).

    Author index. Keyword index.
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