The book is comprised of five parts, Microdosimetry, Bystander effect and transformation, Apoptosis (cell death) and signal transduction, Adaptive responses and immune responses, Cancer and epidemiology, including a series of papers to represent the progress going on, which undoubtedly will make an important contribution to this research field. There are 22 papers ranging from the theoretical considerations, for example, The dual response to low-dose irradiation:: induction vs. prevention of DNA damage by Dr. Feinendegen et al., in which they discussed the net dose-risk function suggesting that the incidence of cancer is less likely to be proportional to dose than to exhibit a threshold, to the experimental studies as well as to epidemiology of cancer risk of a large population lived in the area exposed to high levels of natural radiation, the Kerala coast, India. Its coverage from mice to human will make it particularly useful for students and health professionals in the fields of radiation research, health physics, environmental protection as well as regulatory control.
The dual response to low-dose irradiation:: Induction vs. prevention of DNA damage (L.E. Feinendegen, V.P. Bond, C.A. Sondhaus). Energy barriers for radiation-induced cellular effects (A.L. Brooks, E.E. Hui, V.P. Bond).
Bystander Effect and Transformation.
A bystander effect of á-particles induces genomic instability in haemopoictic cells (E.G.Wright). Radiation-induced transformation of human cells in vitro (A. Riches, C. Peddie).
Apoptosis, Cell Death and Signal Transduction.
Time-course of apoptosis induction in mouse spleen and thymus after whole body X-irradiation with fractionated low doses (K. Fujia et al.). Effects of low-dose preirradiation on radiation-induced cell death in cultured mammalian cells (K. Sakai). Radiation response of p53 and WAF1 accumulation after chronic or acute irradiation (A. Takahashi, K. Ohnishi, T. Ohnishi). The effects of small doses of radiation on intestinal stem cells (C.S. Potten, D. Booth).
Adaptive Responses and Immune responses.
Radioadaptive response:: its variability in cultured human lymphocytes (T. lkushima, S.M.J. Mortazavi). The duration of radioadaptive response in mouse bone marrow cells in vivo (D. Y. Klokov et al.). Radioadaptive survival response in mice (M. Yonezawa). Suppression of ROS-related disease in mouse models by low-dose ă-ray irradiation (T. Nomuraet al.). Activation of macrophages by low-dose in vivo ă-irradiation and its mechanism (R. Goto, Y. Ibuki). Induction of glutathione in mouse brain by low dose of ă-rays (S. Kojima, K. Yamaoka). On mechanistic studies of immune responses following low dose ionizing radiation (S.-Z. Liu and O. Bai).
Cancer and Epidemiology.
Concerted DNA repair and apoptosis responsible for threshold effects in radiation risk (S. Kondo). Dose-rate effect on radon-induced lung carcinogenesis (G. Monchaux, J. P. Morlier). Threshold dose in radiation carcinogenesis (H. Tanooka). Threshold dose and dose-rate for thymic lymphoma inducation and life shortening in mice administered tritiated drinking water (O. Yamamoto, T. Seyama). How dangerous is residential radon? (K. Becker). High natural radiation and cancer in Karunagappally, Kerala, India (M.K. Nair et al.). Genetic epidemiological studies in the high level natural radiation (HLNR) areas of Kerala in the south west coast of India (G. Jaikrishanet al.).
Index of authors.
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