Eating disorders are associated with dangerous and costly medical morbidity, high rates of comorbid psychopathology, significant psychosocial impairment, substantial economic burden, and the highest mortality rate of any psychiatric disorder. These serious disorders have a long history in psychological research, yet advances in neurobiology are relatively new.The Handbook of the Neurobiology of Eating Disorders provides readers with a useful and accessible reference that summarizes and highlights critical findings in eating disorders to provide foundational knowledge of biological and brain function in eating disorders, how this relates to symptom expression and maintenance, and how this can inform future research and treatment development efforts needed to improve efficacy. The book aims not only to assemble scientific information from arange of areas of neurobiology of eating disorders but also to promote discourse and encourage integration of perspectives. By highlighting the controversies in the field, the book clarifies the distinctions between what is known from the data and what is not yet known, to drive further discovery toward thecommon goal of improving understanding and treatment of eating disorders.
List of Figures; List of Tables; Acknowledgments; List of Contributors; Introduction; Part I Overviews; Overview of the Classification and Epidemiology of Eating Disorders; Neurobiology of Ingestive Behavior; Neuroendocrine Function and the Gut-Brain Axis in Eating Disorders; Genetics of Eating Disorders; Computational Psychiatry and Eating Disorders; Part II Basic Neuroscience Domains in Eating Disorders (Bottom Up); Appetite Regulation and Motivation to Eat; Reward Processing and Reinforcement Learning in Eating Disorders; Interoception in Eating Disorders; Social Cognition and Processing in Eating Disorders; Inhibitory Control in Binge-Type Eating Disorders; Cognitive Flexibility in Eating Disorders; Self-Regulation in Eating Disorders; Visuospatial and Neuropsychological Functions in Eating Disorders; Part III Manifest Symptoms of Eating Disorders (Top Down); Restrictive Eating Through the Lens of Choice; Binge Eating; Physical Activity and Exercise; Body Image; Part IV Emerging Neurobiologically Informed Treatments; Habit-Centered Treatment for Anorexia Nervosa; Temperament-Informed Treatment for Anorexia Nervosa; Interoceptive Exposure: Developing Capacities to Discriminate and Adaptively Respond to Visceral Signals; Neurosurgery and Neuromodulation for Eating Disorders; Part V Emerging Topics; Advances in the Activity-Based Anorexia Paradigm: An Animal Model for Aspects of Anorexia Nervosa; Neurobiological Model of Avoidant/Restrictive Food Intake Disorder; The Microbiome-Gut-Brain Axis in Anorexia Nervosa; Target Engagement and Pharmacotherapy in Eating Disorders; The Potential of Psychedelics in the Treatment of Eating Disorders; Afterword; Index;
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