Topics in this exciting, state-of-the-art compilation on depression include:: Novel concepts on Cellular Mechanisms in Depression , Treatment-resistant depression:: Lessons from STAR*D, Somatic therapies for TRD:: New Neurotherapeutics, Update and critique of natural remedies as antidepressant treatments, Comorbid alcohol and substance abuse/dependence in depression:: impact on the outcome of antidepressant treatment, Comorbid medical illness:: impact on the outcome of antidepressant treatment, Genetic and pharmacogenetic studies in depression, Correlates of antidepressant treatment outcome from neuroimaging studies in depression, The promise of quantitative EEG as predictor of treatment outcome in MDD