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Epigenetics in Psychiatry

Epigenetics in Psychiatry

9780128235775
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Description

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.

This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

 

  • Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease
  • Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins
  • Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery
  • Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS)
  • Features chapter contributions from international leaders in the field
Product Details
Academic Press
99880
9780128235775
9780128235775

Data sheet

Publication date
2021
Issue number
2
Cover
paperback
Pages count
846
Dimensions (mm)
191 x 235
Weight (g)
1650

  • Part 1: General Aspects of Epigenetics in Psychiatry

    1. Introduction to Epigenetics in Psychiatry
    Dimitrios Avramopoulos and Richard S. Lee

    2. Outline of Epigenetics
    Sebanti Ganguly, Trygve Tollefsbol and Bidisha Paul

    3. A Brief History of Epigenetics in Psychiatry
    Jacob Peedicayil

    4. Roles of Epigenetics in the Neural Stem Cell and Neuron
    Kinichi Nakashima

    5. Role of Epigenetics in the Brain
    Tania Roth, Stephanie Matt and Eric Roth

    6. Epigenetic Epidemiology of Psychiatric Disorders
    Monica Uddin and Jan Dahrendorff

    7. ATAC-seq and Psychiatric Disorders
    Panos Roussos

    8. Single Cell RNA Sequencing and Psychiatric Disorders
    W. Brad Ruzicka

    9. Single Cell Analysis and Psychiatric Disorders
    James H. Eberwine

    10. Laboratory Techniques in Psychiatric Epigenetics
    Chris Murgatroyd

    11. Laboratory Epigenetic Models of Schizophrenia
    Dennis R. Grayson and Jeffrey Dunn

    12. Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
    Jacob Peedicayil

    Part 2: Epigenetics of Psychiatric Disorders

    13. 5-Methycytosine and 5-Hydroxymethylcytosine in Schizophrenia
    Dennis R. Grayson and Jeffrey Dunn

    14. Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
    Hamid M. Abdolmaleky

    15. Non-Coding RNAs and Psychiatric Disorders
    Jacob Peedicayil and Natalie J. Beveridge

    16. Epigenetics of Bipolar Disorder
    Gabriel Rodrigo Fries, Camila Nayane de Carvalho Lima, Erika Salarda and Omar Farookh Pinjari

    17. Epigenetics in Major Depressive Disorder
    James B. Potash

    18. The Epigenetics of Suicide: The Critical Impact of Environment on Epigenetic Regulation in Suicide
    Benoit Labonté, Gustavo Turecki and Pierre-Eric Lutz

    19. Epigenetics in Posttraumatic Stress Disorder
    Richard G. Hunter

    20. Epigenetics and Cognitive Disorders
    Fabio Coppede and Andrea Stoccoro

    21. Epigenetics in Intellectual Disability
    Jamie M. Kramer, Nathalie Berube, Katherine Quesnel and Taryn Jakub

    22. Epigenetics and Pervasive Developmental Disorders
    Andrea Lynne Gropman

    23. Epigenetics in Child Psychiatry
    Josephine Elia

    24. Epigenetic Mechanisms of Drug Addiction Vulnerability
    Deena Marie Walker, Cari Bendersky and Allison Milian

    25. Epigenetics and Addiction to Alcohol
    Eleonora Gatta, Alessandro Guidotti and Vikram Saudagar

    Part 3: Epigenetics in the Therapy of Psychiatric Disorders

    26. Epigenetic Effects of Currently Used Psychotropic Drugs
    Jacob Peedicayil and Samuel Santosh

    27. DNA Methyltransferase Inhibitors and Psychiatric Disorders
    Marija Kundakovic

    28. Histone Deacetylase Inhibitors and Psychiatric Disorders
    Arvind Kumar

    29. Psychotherapy and Epigenetics in Psychiatry
    Anthony S. Zannas

    30. Gene-Specific Editing for Manipulating Specific Psychiatric Disorders
    Kristen J. Brennand

    Part 4: Other Topics in Epigenetics in Psychiatry

    31. Nutritional Effects on Epigenetics in Psychiatry
    Jacob Peedicayil

    32. Systems Biology and the Epigenetics of Psychiatric disorders
    Jacob Peedicayil

    33. Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
    Tamara Brook Franklin and Katharina Gapp

    34. Epigenetic Aspects of the Microbiome and Psychiatric Disorders
    Jacob Peedicayil and Samuel Santosh

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