Botox injection procedures performed by facial plastic surgeons have increased by 31% in the last year. Dr. Corey Maas, Guest Editor of this issue, is a key consultant in the research and development of injectable materials and is an authority in proper injection techniques of dermal fillers and neurotoxins. This issue of the Clinics covers soft tissue fillers and neurotoxins and discusses anatomic considerations, complications, special indications, along with upcoming products and techniques. Contents:: Relevant neuromuscular facial anatomy; Biochemistry and products on the horizon; Functional applications; Cosmetic treatments and strategies for the upper face; Cosmetic treatments and strategies for the lower face and neck; Complications; Collagen fillers; Hyaluronic acid fillers - Restylane and Perlane; Hyaluronic acid fillers - Hylaform and Captique; Calcium hyroxyapatite; Polylactic acid; Fat transplantation; Autogenous and homogeneic materials; Synthetic soft tissue substitutes; Special Indications - Fillers in the Periorbital complex.