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Multiple Cholecystokinin Receptors in the CNS

Multiple Cholecystokinin Receptors in the CNS

9780198577560
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Description
Cholecystokinin (CCK) is found in high concentrations in mammalian brain where it appears to act as a neurotransmitter. CCK has been implicated in a number of important physiological processes and disease states, including feeding and feeding disorders, nociception, schizophrenia, movement disorders, anxiety, and panic disorder. The recent increase in interest in CCK is mainly attributable to the development of potent selective CCK receptor antagonists. These drugs have proved tobe valuable research tools and may also prove useful as therapeutic agents. This volume reviews the most recent data on the role of CCK in normal and abnormal brain function. It brings together contributions from the leading researchers in the field of CCK neurobiology. Particular emphasis is placed on the roles of CCK receptor subtypes (CCKA and CCKB) which have been determined using selective antagonists. This volume reviews the most recent data on the role of CCK in the central nervous system.
Product Details
OUP Oxford
86686
9780198577560
9780198577560

Data sheet

Publication date
1992
Issue number
1
Cover
hard cover
Pages count
578
Dimensions (mm)
156 x 234
Weight (g)
996
  • PART I:: CCK Neurons and Receptors in the CNS; Introduction; Synthesis of Non-Peptide CCK Antagonists; A Novel Series of Non-Peptide CCK and Gastrin-Anatagonists:: Medicinal Chemistry and Electrophysiological Demonstration of Antagonism; Distribution of Brain Neuronal CCK. An In Situ Hybridization Study; Detection of CCK Receptor Subtypes in Mammalian Brain Using Highly Selective Non-Peptide Antagonists; In Vitro and In Vivo Characterization of CCK B Receptors and Behavioural Responses Induced by Mesolimbic CCK Receptor Stimulation with Compounds Designed to Selectively Recognize CCK A Sites or CCK B Sites; Agonist and Antagonist Pharmacology of CCK-Receptor-Mediated Responses of Rat Ventromedial Hypothalmic Neurons; Studies of Gastrin/CCK Receptors Using Functional Isolated Preparations; Blood-Brain Transfer of the CCK Antagonists L365,260 and Devazepide; PART II:: CCK and Anxiety; Introduction; CCK Receptors and Panic Attacks in Man; Ethological Analysis of the Role of CCK in Anxiety; CCK Receptors and Anxiety in Rats; Anxiogenic-Like Effect of CCK-8 Micro-Injected into the Dorsal Periaqueductal Grey of Rats in the Elevated Plus Maze; Central Actions of CCK:: Modulation and GABA Release by CCK; PART III:: CCK and Satiety; Introduction; The Development and Proof of the CCK Hypothesis of Satiety; Gastric Mechanisms in CCK Satiety; CKK as a Putative Satiety Factor in Farm Animals; Plasma and Cerebrospinal Fluid Concentrations of CCK and Satiety; Behavioural Analysis of the Role of CCK A and CCK B Receptors in the Control of Feeding in Rodents; Evidence that Hypolocomotion Induced by Peripheral or Central Injection of CCK in the Mouse is Mediated by Peripherally-Located CCKA Receptors; CCK-Monoamine Interactions and Satiety in Rodents; Selective CCK Receptor Antagonists and Macronutrient Consumption in the Rat; CCK 5-HT Interactions Influence Meal Size in the Free-feeding Rat; Effects of CCK Receptor Blockade on Hunger and Gastric Emptying in Humans; CCK, Gastric Emptying, and Satiety in Man; Satiation in Humans Induced by the Dipeptide L-aspartyl-L-phenylalanine Methyl Ester (Aspartame):: Possible Involvement of CCK; CCK-induced Activation of Oxytocin Neurons is Blocked by a Selective CCK Receptor Antagonist; C-fos mRNA in Oxytocin Neurons:: Selective Induction by CCK; PART IV:: CCK Dopamine Interactions; Introduction; Immunohistochemical and In Situ Hybridization Studies of the Co-existence of CCK and Dopamine in Mesencephalic Neurons; A study of the Coexpression of CCK and Tyorsine Hydroxylase Messenger RNAs in the Rat Substantia Nigra; Does Hippocampal CCK Influence Dopaminergic Input to the Nucleus Accumbens? Some Anatomical Observations; Functional Analyses of Coexistence of CCK and Dopamine; CCK-dopamine Interactions:: Implications for Treatment of Schizophrenia; CCK:: Its Role in Dopamine-related Disorders; CCK in Exxperimental Models of Dyskinesia; CCK and Movement Disorders; Behavioral and Neurochemical Evidence for an Interaction of CCK with D1 Dopamine-receptors; Involvement of Central Dopamine and CCK-A Receptors in the Apomorphine-induced Hypotensive Response in the Anesthetized Rat; PART V. CCK and Opioid Analgesia; Introduction; CCK and Opioid Analgesia; The Role of CCK-A and CCK-B Receptors in Mediating the Inhibitory Effect of CCK on Opioid Analgesia; The Role of CCK in Electro-acupuncture Analgesia and Electro-acupuncture Tolerance; CCK and Opioid Interactions in the Spinal Cord; Opioid Control of CCK release from the Rat Spinal Cord - Interaction between µ, *s, and ? receptors; In Vivo Release of CCK-8 from the Dorsal Horn of the Rat:: Modulation by Selective Opioid Agonists; Seeking a Role for CCK in Control of Spinal Reflexes; Enhancement of Opiaite Analgesia by Devazepide in in a Baboon Dolorimetry Model; Blockade of CCK-B Receptors by L365,260 induces Analgesia in the Squirrel Monkey;
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