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Insulin - The Crooked Timber

Insulin - The Crooked Timber

A History from Thick Brown Muck to Wall Street Gold

9780192855381
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Description
Before the discovery of insulin, a diagnosis of Type 1 diabetes was a death sentence. One hundred years after a milestone medical discovery, Insulin - The Crooked Timber tells the story of how insulin was transformed from what one clinician called thick brown muck into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Yet when Canadian doctor Frederick Banting was told in 1923 that he had won the Nobel Prize for this life-saving discovery, he was furious. For the prize had not been awarded to him alone - but jointly with a man whom he felt had no right to this honour. The human story behind this discovery is one of ongoing political and scientific controversy. Taking the reader on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, Insulin - The Crooked Timber reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes such as two little known scientists whose work on wool fibres, carried out in a fume-filled former stable, not only proved to be crucial in unravelling the puzzle of insulin but ushered in a revolution in biology. It was the authors own shocking diagnosis with Type 1 diabetes that prompted him to sit down and write this book, but this story has lessons for us all about what technology can - and more importantly cannot - do for us. As the world pins its hopes on effective and lasting vaccines against Covid-19, these lessons from the story of insulin have never been more relevant.
Product Details
OUP Oxford
93470
9780192855381
9780192855381

Data sheet

Publication date
2022
Issue number
1
Cover
hard cover
Pages count
480
Dimensions (mm)
156 x 234
Weight (g)
946
  • Preface; Looking a Gift Horse in the Mouth?; Introduction; Taming the Tiger; The Pissing Evil - a colourful description of diabetes by 17th century English physician Thomas Willis; Thick Brown Muck - Canadian scientist Fred Banting wins the Nobel Prize for the discovery of insulin... and is furious; The Vision of Ezekiel - clinicians are stunned at the power of insulin to save lives, but it proves to be a double-edged sword; A Greek Tragedy - German clinician Georg Zuelzer snatches defeat from the jaws of victory; The Wasps Nest - insulin proves to be a poisoned chalice for its discoverers; Be Careful What You Wish For - the case of Romanian scientist Nicolai Paulesco underlines the truth of an old proverb; In Praise of Wool - the humble wool fibre sets in motion a revolution in biochemistry; A Boastful Undertaking - a discovery made in a fume-filled stable offers the key to unlocking insulin; The Blobs That Won a Nobel Prize - or two, all thanks to some coloured spots on a piece of filter paper; The Prophet in the Labyrinth - biochemist Erwin Chargaff helps unlock the secrets of DNA, but fears where this may lead; The Clone Wars - a conflict in which insulin proves to be a decisive weapon; Wall Street Gold - in an act of modern day alchemy, insulin makes stock market history; Dont You Want Cheap Insulin? - What is it exactly that we want from science? And does the story of insulin have any lessons for us today?; Bibliography; Figures List and Acknowledgements for Images; Acknowledgements; End notes;
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