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Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition

9780071603935
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Description

A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics

The fields leading text for more than three decades

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.

Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to::

  • Understand the basic concepts in biopharmaceutics and pharmacokinetics.
  • Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and elimination
  • Critically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalency
  • Design and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parameters
  • Detect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve them

Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Product Details
50530
9780071603935
9780071603935

Data sheet

Publication date
2012
Issue number
6
Cover
hard cover
Pages count
811
Dimensions (mm)
191 x 239
Weight (g)
1364
  • Preface

    Glossary

    1. Intrtoduction to Biopharmaceutics and Pharmacokinetics

    2. Mathematical Fundamentals in Pharmacokinetics

    3. One-compartment Open Model:: Intravenous Bolus Administration

    5. Intravenous Infusion

    6. Drug Elimination and clearance

    7. Pharmacokinetics of Oral Absorption

    8. Multiple-Dosage Regimens

    9. Monlinear Pharmacokinetics

    10. Physiologic Drub Distribution and Protein Binding

    11. Drug Elimination and Hepatic Clearance

    12. Pharmacogenetics

    13. Physioloic Factors Related to Drug Absorption

    14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance

    15. Drug Product Performance, In Vivo:: Bioavailability and Bioequivalence

    16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy

    17. Modified-Release Drug Products

    18. Targeted Drug Delivery Symptoms and Biotechnological Products

    19. Relationship Between Pharmacokeinetics and Pharmacodynamics

    20. Application of Pharmacokinetics to Clinical Situations

    21. Dose Adjustment in Renal and Hepatic Disease

    Appendix A Statistics

    Appendix B Applications of Computer in Pharmacokinetcs

    Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions

    Appendix D Guiding Prinicples for Human and Animal Research

    Appendix E Popular Drugs and Pharmacokinetic Parameters

    Index

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