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Clinical Pharmacokinetics and Pharmacodynamics

Clinical Pharmacokinetics and Pharmacodynamics

Concepts and Applications

9780781750097
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Description
Formerly Clinical Pharmacokinetics:: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics:: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
Product Details
LWW
44002
9780781750097
9780781750097

Data sheet

Publication date
2010
Issue number
4
Cover
hard cover
Pages count
864
Dimensions (mm)
4516 x 6452
Weight (g)
1740
  • Preface

    Definition of Symbols

    Non-Proprietary and Brand Names of Drugs in Text and Illustrations

    I. Basic Considerations
    1. Therapeutic Relevance
    2. Fundamental Concepts and Terminology

    II. Exposure and Response after a Single Dose
    3. Kinetics Following an Intravenous Bolus Dose
    4. Membranes and Distribution
    5. Elimination
    6. Kinetics Following an Extravascular Dose
    7. Absorption
    8. Response Following a Single Dose

    III. Therapeutic Regimens
    9. Therapeutic Window
    10. Constant-Rate Input
    11. Multiple Dose Regimens

    IV. Individualization
    12.Variability
    13.Genetics
    14. Age, Weight, and Gender
    15. Disease
    16. Nonlinearities
    17. Drug Interactions
    18. Initiating and Managing Therapy

    V. Supplemental Topics
    19. Distribution Kinetics
    20. Metabolites and Drug Response
    21. New! Protein Drugs
    22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data

    Appendices
    A. Assessment of AUC
    B. Ionization and the pH Partition Hypothesis
    C. Distribution of Drugs Extensively Bound to Plasma Proteins
    D. Plasma-to-Blood Concentration Ratio
    E. Well-stirred Model of Hepatic Clearance
    F. Absorption Kinetics
    G. Wagner-Nelson Method
    H. Mean Residence Time
    I. Amount of Drug in Body on Accumulation to Plateau
    J. Answers to Study Problems
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