Review of Organic Functional Groups

Introduction to Medicinal Organic Chemistry

Authors:

Thomas L. Lemke

Brand: Lippincott Williams & Wilkins

ISBN: 9780781743815

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Description

Designed to be used as a self-paced review, this text outlines the functional groups common to organic chemistry, reviewing the general topics of nomenclature, physical and chemical properties, and metabolism. The text provides background material for the formal pharmacy courses in medicinal chemistry, easing the transition from general organic chemistry courses required of all pre-pharmacy students. The Fourth Edition will include a workbook on CD-ROM as well as an index on general drug metabolism. Students who use this text are able to complete difficult tasks such as:: drawing a chemical structure or official chemical name; predicting solubility of chemicals in liquids; predicting and showing, with chemical structures, the metabolism of organic functional groups; predicting and showing instabilities, with chemical structures.

Product Details

Brand Lippincott Williams & Wilkins

Reference 38920

EAN13 9780781743815

ISBN 9780781743815

Data sheet

Publication date: 2003
Issue number: 4
Cover: paperback
Pages count: 160
Dimensions (mm): 156 x 235
Weight (g): 227

1. Water Solubility and Chemical Bonding, 1
  - Van der Waals Attraction (Forces), 1
  - Dipole-Dipole Bonding (Hydrogen Bond), 2
  - Ionic Attraction, 3
  - Ion-Dipole Bonding, 4
2. Alkanes (C_nH_{2n 2}), 6
3. Alkenes (C_nH_{2 n}), 11
  - Cycloalkanes:: Alkene Isomers, 14
4. Aromatic Hydrocarbons, 16
5. Halogenated Hydrocarbons, 19
6. Alcohols, 21
7. Phenols, 25
8. Ethers, 30
9. Aldehydes and Ketones, 33
10. Amines, 38
  - Quaternary Ammonium Salts, 46
11. Carboxylic Acids, 48
12. Functional Derivatives of Carboxylic Acids, 56
  - Esters, 56
  - Amides, 59
  - Carbonates, Carbamates, and Ureas, 62
  - Amidines and Guanidines, 64
13. Sulfonic Acids and Sulfonamides, 66
  - Sulfonic Acids, 66
  - Sulfonamides, 66
14. Thioethers and Nitro Groups, 69
  - Thioethers, 69
  - Nitro Groups, 70
15. Heterocycles, 71
  - Three-Membered Ring Heterocycles, 71
  - Four-Membered Ring Heterocycles, 74
  - Five-Membered Ring Heterocycles, 75
  - Five-Membered Ring Heterocycles With Two or More Heteroatoms, 80
  - Six-Membered Ring Heterocycles, 87
  - Six-Membered Ring Heterocycles With Two Heteroatoms, 88
  - Saturated Six-Membered Heterocycles, 94
  - Seven- And Eight-Membered Ring Heterocycles, 94
  - Bicyclic Heterocycles:: Five-Membered Ring Plus Six-Membered Ring, 95
  - Bicyclic Heterocycles:: Six-Membered Ring Plus Six-Membered Ring, 100
  - Bicyclic Heterocycles:: Six-Membered Ring Plus Seven-Membered Ring, 103
  - Tricyclic Heterocycles, 104
16. Oligonucleotides and Nucleic Acids, 106
17. Proteins, 112
18. Predicting Water Solubility, 122
  - Empiric Method, 122
  - Analytic Method, 126
1. Stereoisomerism—Asymmetric Molecules, 129
2. Acidity and Basicity, 132
  - Definitions of Acids and Bases, 132
  - Relative Strengths of Acids and Bases, 134
  - Reaction of an Acid With a Base in Water, 136
  - Acidic and Basic Organic Function Groups, 138
3. Drug Metabolism, 141
  - Oxygenase Enzymes, 141
  - Hydrolase Enzymes, 145
  - Conjugation Reactions, 145
  Index, 149