In nature, many physical processes are governed by the passage of time. The study of these processes, chronobiology, reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns. Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks, solely in relation to humans. Comprehensive discussion is given to specific diseases, which are time dependent, and the drugs and new drug formulations that can be used as treatments. Written by international experts in the field, Chronotherapeutics provides contemporary information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences.
1. An Introduction to Circadian Rhythms and Their Measurement in Humans; 2. The Biological Clock-location, Neuroanatomy and Neurochemistry; 3. The Molecular Biology of the Mammalian Circadian Clock; 4. Rhythms and Pharmacokinetics; 5. Rhythms and Pharmacodynamics; 6. Rhythms and Therapeutics of Diseases of the Gastrointestinal Tract; 7. Rhythms and Therapeutics of Asthma; 8. Rhythms and Therapeutics of Cardiovascular Disease; 9. Rhythms, Pain and Pain Management; 10. Rhythms of Cancer Chemotherapy; 11. Chronopharmaceutical Drug Delivery; 12. Circadian Rhythm Abnormalities; 13. Drug Effects on Suprachiasmatic Nucleus Function; 14. The Effect of Melatonin Secretion: Clinical Aspects; 15. Chronobiological Mechanisms in Seasonal Affective Disorder.
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