Pharmacology can be defined as a discipline of paramedical sciences that teaches how the use of drugs can bring about changes from pathological states to physiological conditions. Whereas mediator pharmacology is a subdivision pharmacology which teaches the functions of molecules released in the body and produces profound pharmacological effects. Also, their sustained release may results in pathological conditions. The agonists or antagonists of these mediators may offer novel therapeutic agents for clinical benefits. This book provides necessary scientific developments in mediator pharmacology.
Preface; Pathogenic Responses of Bradykinin System in Chronic Inflammatory Rheumatoid Disease; Interrelationship between the kallikrein-kinin system & hypertension; The Role of Chemical Mediators in the Pathogenesis of Inflammation with Emphasis on the Kinin System; Mediation of Kallikrein-kinin system in the mechanism of action of angiotensin converting enzyme inhibitors; The Kinin System & Prostaglandins in the Intestine; Proinflammatory actions of the platelet activating factor:: Relevance to rheumatoid arthritis; Role of Tissue Kallikrein-Kininogen-Kinin Pathways in the Cardiovascular System; Role of Nitric Oxide in Inflammatory Diseases; The role of leukotrienes in the pathophysiology of inflammatory Disorders:: Is there a case for revisiting leukotrienes as therapeutic targets?; Therapeutic prospects for bradykinin receptor agonists in the treatment of cardiovascular diseases; Therapeutic prospects of bradykinin receptor antagonists; Index.
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