Biogenic amines are naturally occurring amines that are derived by enzymic decarboxylation of the natural amino acids. They belong to a class of neurotransmitters including catecholamines (dopamine, norepinephrine, and epinephrine), indolamine (serotonin), and imidazoleamine (histamine). Biogenic amines have great pharmacological and physiological importance. The main objective of this book is to present readers with comprehensive information on pharmacology, neurochemistry and molecular neurobiology of biogenic amine in the CNS of vertebrate and invertebrates in a single volume text. The book has been organised into chapters and sections to provide a better flow of information. Furthermore, this unique volume provides its readers with cutting edge information on biogenic amines. It can be used by graduate students, postdoctoral fellows, researchers, and scientists who work at the pharmaceutical industry as a handbook, which describes all aspects of biogenic amine metabolism.
Foreword; Preface; Biogenic Amines:: A Historical Perspective; Lifes Requirements for Catecholamines; Aromatic L-amino Acid Decarboxylase; Striatal Dopamine Storage & Utilisation; The Importance of Monoamine Transporters in the Development of Psychopharmacology; Amine False Transmitters & Volume Transmission:: Fifty Years of Exceptions; Pharmacological Approaches for the Evaluation of Drug-Receptor Related Events; What Has 6-Hydroxydopamine Taught Us About Parkinsons Disease?; The Molecular & Genetic Basis of Parkinson Disease; Modulation of Neurotransmission Signaling by Neural Membrane Polyunsaturated Fatty Acids; Estrogen-Dopamine Interactions in Forebrain Modulation of the Sensorimotor Gating; Stereoselectivity of Norepinephrine Enantiomers at Pre & Post- Junctional Adrenoceptors; Trace amines & Their Receptors Comprise a Novel Vertebrate Aminergic Signalling System; Quantification of Octopamine in Invertebrate & Vertebrate Nervous Systems; Pharmacology of invertebrate octopamine & tyramine receptors; The Cellular & Molecular Biology of Octopaminergic Neurons; Perspective & Future Developments on Biogenic Amines in the CNS; Index.
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