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Drug Discovery and Development

Drug Discovery and Development

Technology in Transition

9780702042997
302.35 zł
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Description

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process:: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development:: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market.

Product Details
Churchill Livingstone
50710
9780702042997
9780702042997

Data sheet

Publication date
2012
Issue number
2
Cover
paperback
Pages count
368
Dimensions (mm)
189 x 246

  • Contents

    SECTION 1

    INTRODUCTION AND BACKGROUND

    1. The development of the pharmaceutical industry

    H P Rang

    2. The nature of disease and the purpose of therapy

    H P Rang, R G Hill

    3. Therapeutic modalities

    H P Rang, H LeVine, R G Hill

    SECTION 2

    DRUG DISCOVERY

    4. The drug discovery process: general principles and some case histories

    H P Rang, R G Hill

    5. Choosing the project

    H P Rang, R G Hill

    6. Choosing the target

    H P Rang, R G Hill

    7. The role of information, bioinformatics and genomics

    B Robson, R McBurney

    8. High-throughput screening

    D Cronk

    9. The role of medicinal chemistry in the drug discovery process

    P Beswick, A Naylor

    10. DMPK optimization strategy in drug discovery

    P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

    11. Pharmacology: its role in drug discovery

    H P Rang

    12. Biopharmaceuticals

    H LeVine

    13. Scaffolds: Small globular proteins as antibody substitutes

    D Grabulovski, J Bertschinger

    SECTION 3

    DRUG DEVELOPMENT

    14. Drug development: introduction

    H P Rang, R G Hill

    15. Assessing drug safety

    H P Rang, R G Hill

    16. Pharmaceutical developmentT Lundqvist, S Bredenberg

    17. Clinical Development - Present and Future

    C Keywood

    18. Clinical imaging in drug development

    P M Matthews

    19. Intellectual property in drug discovery and development

    P Grubb

    20. Regulatory affairs

    I Hägglöf, Ĺ Holmgren

    21. Marketing the drug

    V L Lawton

    SECTION 4

    FACTS AND FIGURES

    22. Drug discovery and development - facts and figures

    H P Rang, R G Hill

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