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Perinatal Neuropathology

Perinatal Neuropathology

9781107159792
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Description

There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource.

  • Approaches the subject matter from a practical standpoint, providing report templates that have been generated by leading experts in the subject that the reader can use as a basis for their own work
  • Contains over 250 high-quality images and illustrations, which will aid the reader in understanding the content
  • Readers can gain full HTML access of the whole book, with expandable figures and resources, via a scratch-off code inside the cover
Product Details
Cambridge University Press
98754
9781107159792

Data sheet

Publication date
2021
Issue number
1
Pages count
458
Dimensions (mm)
225.00 x 284.00

  • Part I. Techniques and Practical Considerations:: Approach to autopsy of perinatal nervous system::
    1. Clinical considerations
    2. Imaging
    3. External exam of fetus/infant
    4. Autopsy and research consent
    Ancillary studies::
    5. Microbiology
    6. Cytogenetics
    7. Metabolic studies
    8. Toxicology
    Prosection techniques::
    9. Brain
    10. Spinal cord
    11. Neuromuscular specimens
    12. Eye specimens
    Tissue selection::
    13. Selection of brain sreas for microscopic examination
    14. Technical considerations in perinatal CNS tissue processing
    15. Staining techniques
    Reporting::
    16. Formulation of diagnosis
    17. Reporting templates
    18. Medicolegal Considerations
    Part II. Human Nervous System Development:: Neuroanatomic Site Development::
    19. Human nervous system development – embryonic and early fetal events
    20. Cerebral cortex, including germinal matrix
    21. White matter, including myelination
    22. Cerebellum development of rhombic Lip, cerebellar cortex, dentate nucleus
    23. Spinal cord
    24. Skeletal muscle and peripheral nerve
    25. Fetal and infant eye
    Growth parameters:: Head size and brain weight
    Part III. Stillbirth:: Autolysis and Artifacts::
    27. Autolysis and artefacts
    Stillbirths::
    28. Stillbirth
    Part IV. Disruptions/Hypoxic-Ischemic Injury:: Cellular Responses::
    29. Neuronal death
    30. Macroglial reactions
    31. Inflammatory responses
    Gray matter::
    32. Supratentorial grey matter damage and disruptions
    33. Brainstem and spinal cord disruptions
    white matter::
    34. Periventricular leukomalacia and diffuse white matter injury
    Germinal matrix::
    35. Periventricular and intraventricular brain hemorrhage
    Cerebellum::
    37. Cerebellar lesions
    Part V. Malformations:: Neural Tube Defects and Patterning Defects::
    37. Defects of neural tube Closure and axial mesodermal defects
    38. Disorders of early midline patterning
    Hydrocephalus:: Fetal and perinatal hydrocephalus
    Neuronal migration disorders::
    40. Cerebral cortical migration disorders
    Genetic syndromes and phacomatoses::
    41. Fragile X syndrome
    42. Down syndrome
    43. Edwardss syndrome
    44. Patau syndrome
    45. Tuberous sclerosis complex
    46. Sturge-weber syndrome
    47. Neurocutaneous melanosis
    Part VI. Congenital and Perinatal Brain Tumors::
    48. Congenital and perinatal brain Tumors
    Part VII. Spinal and Neuromuscular Disorders
    Arthrogryposis::
    49. Arthrogryposis
    Spinal muscle atrophy (SMN AND NON-5Q SMA)::
    50. SMN and non-5q sMA,
    Early-Onset hereditary neuropathies::
    51. CMT neuropathies
    Congenital muscle disorders::
    52. Congenital myasthenic syndromes
    53. Congenital muscular dystrophies
    54. Congenital myopathies
    55. Other congenital muscle diseases
    Part VIII. Eye Disorders:: Congenital Eye Disorders::
    56. Congenital eye malformations and Deformations
    Part IX. Infections in Utero Infections:: Congenital viral, bacterial, and parasitic infections
    Peri- and postnatal infections::
    58. Meningitis and encephalitis
    Part X. Metabolic/Toxic Disorders:: Storage diseases:: Lysosomal Disorders
    60. Peroxisomal Disorders
    Kernicterus::
    61. Kernicterus
    Mitochondrial diseases::
    62.Mitochondrial diseases
    Maternal toxin exposure::
    63. Ethanol and other agents
    Part XI. Forensic Neuropathology:: Trauma::
    64. Birth trauma
    65. Accidental and non-accidental death
    Sudden unexpected death in infancy and childhood::
    66. Sudden unexpected death in infancy and childhood.

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