The presentation of hematolymphoid and histiocytic diseases can vary widely between children and adults as can age-related differential diagnoses and the consequences of treatment. Providing up to date information and classification for diseases across the hematopoietic, lymphoid and histiocytic systems, the book also covers morphologic, immunophenotypic, cytogenetic, and molecular genetic features of routine and diagnostically challenging disorders in pediatric patients. Over 200 high-quality colour illustrations aid accurate diagnosis and correct interpretations when evaluating peripheral blood, bone marrow, lymph nodes and other tissues specimens. This comprehensive yet practical guide also discusses useful ancillary tests and introduces newly recognised entities identified in the current literature, such as GATA-2 haploinsufficiency, B-ALL with DUX4-IGH and ERG deletion, and ALK-positive histiocytosis. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.
Section I. General Hematology and Hematopathology: 1. Development of hematopoiesis in fetus, at birth and after birth Xiayuan Liang; 2. Normal anatomy and function of lymph node Xiayuan Lian; Section II. Non-Neoplastic Hematologic Disorders of Blood and Bone Marrow: 3. Anemia Virginia Knez and Xiayuan Liang; 4. Bone marrow failure syndromes Bradford Siegele; 5. Inherited leukocyte disorders Bradford Siegele; 6. Other conditions Virginia Knez and Xiayuan Liang; Section III. Non-Neoplastic Disorders of Extramedullary Lymphoid Tissues: 7. Non-infectious lymphadenopathy Xiayuan Liang; 8. Infectious lymphadenopathy Julie Rosser and Xiayuan Liang; Section IV. Neoplastic Disorders Of Bone Marrow: 9. Ancillary tests Bradford Siegele, Liming Bao, Amy L. Treece and Xiayuan Liang; 10. Juvenile myelomonocytic leukemia Bradford Siegele; 11. Myeloid/lymphoid neoplasms with eosinophilia & gene rearrangement Bradford Siegele; 12. Myelodysplastic/myeloproliferative neoplasms/Chronic myeloid leukemia, BCR-ABL1+ Bradford Siegele; 13. Childhood myelodysplastic syndromes (MDS) Bradford Siegele; 14. Acyte myeloid leukemia with related precursor neoplasms Xiayuan Liang, Billie Carstens and Virginia Knez; 15. Myeloid neoplasms with germline predisposition Bradford Siegele; 16. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) Bradford Siegele; 17. Acute luekemia of ambiguous lineage Xiayuan Liang and Silvia Tse Bunting; 18. Precursor lymphoid neoplasms Virginia Knez, Alexandra E. Kovach, Gordana Raca, Billie Carstens and Xiayuan Liang; 19. Solid tumor metastasis to the bone marrow Xiayuan Liang; Section V. Mature Lymphoid Neoplasms: 20. Mature b-cell non-hodgkin neoplasms Xiayuan Liang; 21. Mature t-cell and nk-cell non-hodgkin lymphomas Xiayuan Liang; 22. Hodgkin lymphoma Xiayuan Liang; 23. Immunedeficiency-assoicated lymphoproliferative disorders Xiayuan Liang; Section VI. Histiocytic Disorders and Neoplasms: 24. Histiocytic pathogenesis and derivation Jennifer Picarsic; 25. Identification of macrophages and dendritic cells Jennifer Picarsic; 26. Non-neoplastic accumulation of histiocytes Jennifer Picarsic; 27. Hemophagocytic lymphohistiocytosis (HLH) Jennifer Picarsic and Rebecca Marsh; 28. Histiocytic inflammatory neoplasms/lesions Jennifer Picarsic, Benjamin H. Durham and Ashish Kumar.
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