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Diagnostic Pathology: Transplant Pathology

Diagnostic Pathology: Transplant Pathology

9780443250088
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Description
This volume in the Diagnostic Pathology series is an ideal point-of-care resource for practitioners at all levels of experience and training. Covering the full range of solid organ transplantation (SOT) of the kidney, liver, heart, lung, pancreas, intestine, and more, it provides a current understanding of transplant immunology and pathology to help ensure accurate diagnosis for optimal clinical management. Richly illustrated and easy to use, Diagnostic Pathology:: Transplant Pathology, third edition, is a visually stunning, one-stop reference for practicing pathologists, transplant practitioners, and students of organ transplantation.
Product Details
Elsevier
100257
9780443250088
9780443250088

Data sheet

Publication date
2024
Issue number
3
Cover
hard cover
Pages count
616
Dimensions (mm)
216 x 276
Weight (g)
1930
  • SECTION 1: IMMUNOLOGY

    4 Immune Response in Organ Transplantation
    Roshini Sarah Abraham, PhD
    8 Regulatory Immune Cells and Transplant Tolerance
    Roshini Sarah Abraham, PhD
    14 Viral Infections and Immune Response
    Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD
    20 Genetics of Complement Variants in Atypical HUS and TMA
    Roshini Sarah Abraham, PhD
    24 Laboratory-Based Immune Monitoring in Organ Transplantation
    Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD
    30 Introduction to Xenotransplantation
    Roshini Sarah Abraham, PhD
    32 Graft-vs.-Host Disease in Solid Organ Transplantation
    Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD

    SECTION2: HLA TESTING

    36 Human Leukocyte Antigen System
    Manish J. Gandhi, MD
    38 Histocompatibility Testing
    Manish J. Gandhi, MD
    40 Transplantation and HLA
    Manish J. Gandhi, MD
    44 ABO Blood Group Antigens and Transplantation
    Manish J. Gandhi, MD
    46 Apheresis and Transplantation
    Manish J. Gandhi, MD
    48 HLA and Transfusion
    Manish J. Gandhi, MD

    SECTION 3: IMMUNOSUPPRESSIVE DRUGS

    52 Mechanism of Action of Immunosuppressive Drugs
    Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD
    54 Therapeutic Drug Monitoring in Transplant Patients
    Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD
    58 History of Immunosuppression Drugs in Transplantation
    Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD

    SECTION 4: KIDNEY TRANSPLANTATION

    62 History of Kidney Transplantation
    Lynn D. Cornell, MD
    64 Pathologic Classification of Renal Allograft Diseases
    Robert B. Colvin, MD
    66 Examination of End-Stage Kidney
    Shane Meehan, MB, BCh
    72 Evaluation of End-Stage Kidney
    Shane Meehan, MB, BCh
    78 Evaluation of Allograft Kidney
    Lynn D. Cornell, MD and Evan Farkash, MD, PhD
    84 Evaluation of Donor Kidney
    Lynn D. Cornell, MD and Evan Farkash, MD, PhD
    90 Evaluation of Transplant Nephrectomy
    Shane Meehan, MB, BCh and Evan Farkash, MD, PhD
    94 Evaluation of Fibrosis
    A. Brad Farris, III, MD, MBA
    98 Protocol Biopsies
    Lynn D. Cornell, MD and Evan Farkash, MD, PhD
    102 Accommodation
    Lynn D. Cornell, MD
    104 Tolerance
    Robert B. Colvin, MD

    SURGICAL COMPLICATIONS

    108 Acute Allograft Ischemia
    A. Brad Farris, III, MD, MBA
    112 Size Mismatch Allograft Injury
    Anthony Chang, MD and Yael K. Heher, MD, MPH
    114 Urine Leak
    A. Brad Farris, III, MD, MBA
    115 Lymphocele
    A. Brad Farris, III, MD, MBA
    116 Multinucleated Endotheliopathy
    Jonathan Zuckerman, MD, PhD
    120 Transplant Renal Artery Stenosis
    A. Brad Farris, III, MD, MBA
    122 Transplant Renal Artery or Vein Thrombosis
    A. Brad Farris, III, MD, MBA
    124 Kidney Xenografts
    Ivy A. Rosales, MD

    ALLOGRAFT REJECTION

    128 Hyperacute Rejection
    Lynn D. Cornell, MD and Michael Mengel, MD
    132 Acute T-Cell-Mediated Rejection
    Lynn D. Cornell, MD and Michael Mengel, MD
    142 Chronic T-Cell-Mediated Rejection
    Lynn D. Cornell, MD and Michael Mengel, MD
    146 Acute Antibody-Mediated Rejection
    Lynn D. Cornell, MD and Michael Mengel, MD
    154 Chronic Antibody-Mediated Rejection
    Lynn D. Cornell, MD and Michael Mengel, MD
    166 Transcript Analysis of Renal Transplant Biopsies
    Michael Mengel, MD and R. Neal Smith, MD, PhD

    RECURRENT AND DE NOVO DISEASES

    170 Diseases That Recur in Allografts
    Anthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD, PhD
    176 De Novo Focal Segmental Glomerulosclerosis
    Anthony Chang, MD and Astrid Weins, MD, PhD
    178 De Novo Membranous Nephropathy
    Anthony Chang, MD
    182 Anti-GBM Disease in Alport Syndrome
    Anthony Chang, MD and R. Neal Smith, MD, PhD
    184 Chimerism Transition Syndrome
    A. Brad Farris, III, MD, MBA
    186 Late Posttransplant Histology
    Lynn D. Cornell, MD

    KIDNEY PATHOLOGY OF RECIPIENTS OF OTHER TRANSPLANTS

    188 Kidney Diseases in Nonrenal Transplant Recipients
    Robert B. Colvin, MD
    192 Graft-vs.-Host Glomerulopathies
    Anthony Chang, MD and Yael K. Heher, MD, MPH

    DRUG TOXICITIES

    194 Calcineurin Inhibitor Toxicity
    Shane Meehan, MB, BCh
    200 mTOR Inhibitor Toxicity
    Lynn D. Cornell, MD

    INFECTIONS

    202 Acute Pyelonephritis
    Neeraja Kambham, MD
    210 Polyomavirus Nephritis
    Anthony Chang, MD and Evan Farkash, MD, PhD
    218 Adenovirus Infection
    Anthony Chang, MD and R. Neal Smith, MD, PhD
    220 Cytomegalovirus Infection
    Anthony Chang, MD and R. Neal Smith, MD, PhD
    222 Mucormycosis
    Anthony Chang, MD
    224 Histoplasmosis
    Anthony Chang, MD
    225 Candidiasis
    Anthony Chang, MD
    226 Cryptococcosis
    Anthony Chang, MD
    227 Aspergillosis
    Anthony Chang, MD
    228 Coccidioidomycosis
    Anthony Chang, MD
    229 Paracoccidioidomycosis
    Anthony Chang, MD
    230 Microsporidiosis
    Robert B. Colvin, MD
    232 Tuberculosis
    Neeraja Kambham, MD
    234 Malakoplakia
    Neeraja Kambham, MD
    238 Nocardiosis
    Neeraja Kambham, MD

    SECTION 5: LIVER TRANSPLANTATION

    242 Pathologic Classification of Liver Allograft Diseases
    Lindsay Alpert, MD and John Hart, MD
    244 Gross Evaluation of Native Liver
    Lindsay Alpert, MD and John Hart, MD
    248 Evaluation of Failed Liver Allograft
    Lindsay Alpert, MD and John Hart, MD
    250 Evaluation of Donor Liver
    John Hart, MD
    254 History of Liver Transplantation
    Anthony Chang, MD and John Hart, MD

    POSTTRANSPLANT SURGICAL COMPLICATIONS

    256 Preservation Injury
    Hanlin L. Wang, MD, PhD
    258 Hepatic Artery Thrombosis
    Lisa Yerian, MD and John Hart, MD
    260 Portal Vein Thrombosis
    Lisa Yerian, MD and John Hart, MD
    262 Bile Duct Stricture, Leak, Sludge, Biloma
    Hanlin L. Wang, MD, PhD
    264 Hepatic Venous Outflow Obstruction
    Hanlin L. Wang, MD, PhD
    268 Small-for-Size (Hyperperfusion) Syndrome
    Hanlin L. Wang, MD, PhD

    ALLOGRAFT REJECTION

    270 T-Cell-Mediated Rejection, Liver
    Lisa Yerian, MD and John Hart, MD
    274 Antibody-Mediated Rejection, Liver
    Hanlin L. Wang, MD, PhD, Robert B. Colvin, MD, and Richard Masia, MD, PhD
    278 Chronic (Ductopenic) Rejection
    Matthew M. Yeh, MD, PhD and John Hart, MD

    RECURRENT DISEASES IN LIVER ALLOGRAFT

    280 Recurrent Hepatitis B Virus
    Lindsay Alpert, MD and John Hart, MD
    282 Recurrent Hepatitis C Virus
    Lindsay Alpert, MD and John Hart, MD
    286 Fibrosing Cholestatic HBV or HCV Hepatitis
    Lindsay Alpert, MD and John Hart, MD
    288 Recurrent Autoimmune Hepatitis
    Lindsay Alpert, MD and John Hart, MD
    290 Recurrent Primary Biliary Cholangitis
    Lindsay Alpert, MD and John Hart, MD
    292 Recurrent Primary Sclerosing Cholangitis
    Lindsay Alpert, MD and John Hart, MD
    294 Recurrent Fatty Liver Disease
    Lindsay Alpert, MD and John Hart, MD

    INFECTIONS

    296 Cytomegalovirus
    Maria Westerhoff, MD and Lei Zhao, MD, PhD
    298 Herpes Simplex Virus
    Maria Westerhoff, MD and Lei Zhao, MD, PhD
    300 Adenovirus, Liver
    Maria Westerhoff, MD and Lei Zhao, MD, PhD
    302 Hepatitis E Virus
    Maria Westerhoff, MD and Lei Zhao, MD, PhD
    304 Epstein-Barr Virus, Liver
    Maria Westerhoff, MD and Lei Zhao, MD, PhD
    308 Fungal Infections, Liver
    Maria Westerhoff, MD and Lei Zhao, MD, PhD

    LATE-GRAFT DYSFUNCTION

    310 Plasma Cell-Rich Rejection
    Lisa Yerian, MD and John Hart, MD
    312 Graft-vs.-Host Disease, Liver
    Lisa Yerian, MD and John Hart, MD

    SECTION 6: HEART TRANSPLANTATION

    316 Pathologic Classification of Cardiac Allograft Diseases
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    318 Evaluation of Failed Native and Transplanted Heart
    Aliya N. Husain, MD and Phillip D. McMullen, MD, PhD
    320 History of Heart Transplantation
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD

    EVALUATION OF EXPLANTED HEART

    322 Ischemic Heart Disease
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    326 Dilated Cardiomyopathy
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    330 Hypertrophic Cardiomyopathy
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    334 Congenital Heart Disease
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    338 Sarcoidosis, Heart
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    340 Arrhythmogenic Cardiomyopathy
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    344 Other Causes of End-Stage Heart Disease
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD

    ALLOGRAFT REJECTION

    350 Acute Cellular Rejection, Heart
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    354 Antibody-Mediated Rejection, Heart
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    356 Chronic Allograft Vasculopathy, Heart
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD

    NONINFECTIOUS LESIONS

    358 Quilty Lesions
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD
    360 Site of Previous Biopsy
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD

    INFECTIONS

    362 Myocarditis
    Phillip D. McMullen, MD, PhD and Aliya N. Husain, MD

    SECTION 7: LUNG TRANSPLANTATION

    370 Pathologic Classification of Lung Allograft Diseases
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    372 Examination of Native and Transplanted Lungs
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    374 History of Lung Transplantation
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    EVALUATION OF FAILED NATIVE LUNG

    376 Emphysema
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    378 Cystic Fibrosis
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    380 Idiopathic Pulmonary Fibrosis
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    382 Connective Tissue Disease-Associated Interstitial Lung Disease
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    384 Sarcoidosis, Lung
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    386 Pulmonary Arterial Hypertension
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    388 Other Causes of End-Stage Lung Disease
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    SURGICAL COMPLICATIONS

    392 Surgical Aspects and Complications, Lung
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    ALLOGRAFT REJECTION

    394 Pathologic Classification of Rejection
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    396 Antibody-Mediated Rejection, Lung
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    398 Acute Cellular Rejection, Grade A
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    400 Acute Cellular Rejection, Grade B
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    402 Chronic Allograft Dysfunction, Lung
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    NONINFECTIOUS LESIONS

    404 Organizing Pneumonia
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    406 Microaspiration
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    INFECTIONS

    408 Bacterial Infections
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    410 Viral Infections
    Jefree J. Schulte, MD and Aliya N. Husain, MD
    414 Fungal Infections, Lung
    Jefree J. Schulte, MD and Aliya N. Husain, MD

    SECTION 8: INTESTINAL TRANSPLANTATION

    420 Pathologic Classification of Intestinal Allograft Diseases
    Sarangarajan Ranganathan, MD
    422 Indications and Evaluation of Explant
    Sarangarajan Ranganathan, MD
    426 Reperfusion Injury
    Sarangarajan Ranganathan, MD
    430 History of Intestinal and Multivisceral Transplantation
    Sarangarajan Ranganathan, MD

    ALLOGRAFT REJECTION/IMMUNOLOGICAL INJURY

    432 Acute Antibody-Mediated Rejection, Intestine
    Sarangarajan Ranganathan, MD
    436 Acute Cellular Rejection, Intestine
    Sarangarajan Ranganathan, MD
    444 Chronic Rejection, Intestine
    Sarangarajan Ranganathan, MD
    448 Stomach Rejection
    Sarangarajan Ranganathan, MD
    452 Colon Rejection
    Sarangarajan Ranganathan, MD
    456 Graft-vs.-Host Disease, Intestine
    Sarangarajan Ranganathan, MD

    INFECTIONS

    460 Bacterial and Fungal Infections
    Sarangarajan Ranganathan, MD
    464 Adenovirus, Intestine
    Sarangarajan Ranganathan, MD
    468 Rotavirus, Cytomegalovirus, and Herpes Simplex Virus
    Sarangarajan Ranganathan, MD
    472 Epstein-Barr Virus, Intestine
    Sarangarajan Ranganathan, MD

    SECTION 9: PANCREAS TRANSPLANTATION

    480 Pathologic Classification of Pancreas Allograft Diseases
    Surya V. Seshan, MD and Billie S. Fyfe, MD
    482 Clinical Considerations in Pancreas Transplant Evaluation
    Surya V. Seshan, MD and Billie S. Fyfe, MD
    488 History of Pancreas Transplantation
    Surya V. Seshan, MD and Billie S. Fyfe, MD
    490 History of Islet Transplantation
    Piotr Witkowski, MD, PhD and Sarah A. Gondek, BS

    SURGICAL COMPLICATIONS

    492 Surgical Aspects and Complications, Pancreas
    Piotr Witkowski, MD, PhD, Sarah A. Gondek, BS, and Surya V. Seshan, MD

    ALLOGRAFT REJECTION

    500 T-Cell-Mediated Rejection, Pancreas
    Surya V. Seshan, MD, Billie S. Fyfe, MD, and Erika R. Bracamonte, MD
    506 Antibody-Mediated Rejection, Pancreas
    Surya V. Seshan, MD and Billie S. Fyfe, MD
    510 Pancreas Allograft Fibrosis/Graft Sclerosis
    Surya V. Seshan, MD, Billie S. Fyfe, MD, and Erika R. Bracamonte, MD

    GRAFT DYSFUNCTION

    514 Recurrent Diabetes Mellitus
    Surya V. Seshan, MD and Billie S. Fyfe, MD
    518 Islet Cell Toxicity and Islet Amyloid Deposition
    Surya V. Seshan, MD and Billie S. Fyfe, MD

    INFECTIONS

    520 Intraabdominal and Opportunistic Infections
    Surya V. Seshan, MD and Billie S. Fyfe, MD

    SECTION 10: VASCULARIZED COMPOSITE ALLOTRANSPLANTATION

    528 History of Vascularized Composite Allotransplantation
    Linda Cendales, MD, J. Andres Hernandez, MD, MBA, and Emmanuel O. Emovon, III, BS
    530 Complications of Vascularized Composite Allotransplantation
    Linda Cendales, MD, J. Andres Hernandez, MD, MBA, and Emmanuel O. Emovon, III, BS

    ALLOGRAFT REJECTION

    532 Acute T-Cell- and Antibody-Mediated Rejection
    A. Brad Farris, III, MD, MBA, Ivy A. Rosales, MD, and Robert B. Colvin, MD
    540 Chronic Rejection
    A. Brad Farris, III, MD, MBA, Robert B. Colvin, MD, and Ivy A. Rosales, MD

    SECTION 11: POSTTRANSPLANT NEOPLASTIC DISORDERS

    544 Posttransplant Lymphoproliferative Diseases
    A. Brad Farris, III, MD, MBA
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