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Diagnostic Pathology: Blood and Bone Marrow

Diagnostic Pathology: Blood and Bone Marrow

9780323878784
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Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to todays practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology:: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Product Details
Elsevier
98212
9780323878784
9780323878784

Data sheet

Publication date
2023
Issue number
3
Cover
hard cover
Pages count
950
Dimensions (mm)
216 x 276
Weight (g)
3060
  • SECTION 1: INTRODUCTION
    4 Hematopoiesis and Bone Marrow Histology
    Kathryn Foucar, MD
    14 Bone Marrow Examination and Techniques
    Kathryn Foucar, MD and Kaaren K. Reichard, MD
    26 Synoptic/Integrated Bone Marrow Reporting and Algorithmic Testing
    Amer Mahmoud, MD, FCAP and Cordelia Sever, MD, FCAP
    30 Overview of Constitutional and Acquired Bone Marrow Disorders
    Kathryn Foucar, MD

    SECTION 2: ANEMIA

    38 Overview of Anemia
    Kathryn Foucar, MD

    ACQUIRED ANEMIAS
    44 Anemias of Inflammation, Chronic Kidney Disease, and Cancer
    Qian-Yun Zhang, MD, PhD
    48 Iron Deficiency Anemia
    Qian-Yun Zhang, MD, PhD
    52 Autoimmune Hemolytic Anemias
    Qian-Yun Zhang, MD, PhD
    58 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
    Qian-Yun Zhang, MD, PhD
    62 Microangiopathic Hemolytic Anemia
    Qian-Yun Zhang, MD, PhD, Jay S. Raval, MD, and Marian Rollins-Raval, MD, MPH
    68 Megaloblastic Anemia
    Kristin Hunt Karner, MD and Daniel Babu, MD
    76 Acquired Nonneoplastic Sideroblastic Anemia
    Brittany Coffman, MD and Kaaren K. Reichard, MD
    80 Alcoholism-Associated Anemia
    Brittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
    84 Anemia in Older Adults
    Kathryn Foucar, MD
    88 Copper Deficiency-Associated Anemia
    Carla S. Wilson, MD, PhD
    92 Acquired Red Cell Aplasia
    Kristin Hunt Karner, MD
    96 Transient Erythroblastopenia of Childhood
    Kathryn Foucar, MD
    98 Parvovirus-Induced Red Cell Aplasia
    Kristin Hunt Karner, MD
    102 Paroxysmal Nocturnal Hemoglobinuria
    Kristin Hunt Karner, MD
    108 Acquired Aplastic Anemia
    Kathryn Foucar, MD and David R. Czuchlewski, MD

    CONSTITUTIONAL ANEMIAS

    112 Thalassemia
    Kristin Hunt Karner, MD
    118 Sickle Cell Anemia
    Kristin Hunt Karner, MD
    122 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
    Brittany Coffman, MD and Kathryn Foucar, MD
    124 Pyruvate Kinase Deficiency
    Kristin Hunt Karner, MD
    126 Hereditary Spherocytosis
    Carla S. Wilson, MD, PhD
    132 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
    Brittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
    136 Diamond-Blackfan Anemia
    David R. Czuchlewski, MD
    140 Fanconi Anemia
    David R. Czuchlewski, MD
    144 Congenital Dyserythropoietic Anemia
    Kathryn Foucar, MD
    150 Congenital Sideroblastic Anemia
    David R. Czuchlewski, MD
    154 Congenital Megaloblastic Anemia
    David R. Czuchlewski, MD

    SECTION 3: ERYTHROCYTOSIS

    CONSTITUTIONAL

    162 Congenital Erythrocytosis
    David R. Czuchlewski, MD

    ACQUIRED
    166 Acquired Erythrocytosis
    Kathryn Foucar, MD

    SECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW

    172 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
    Kathryn Foucar, MD
    176 Pancytopenia
    Kathryn Foucar, MD
    184 Neutropenia
    Kathryn Foucar, MD
    190 Neutrophilia
    Kathryn Foucar, MD
    196 Monocytosis
    Carla S. Wilson, MD, PhD
    202 Eosinophilia
    Carla S. Wilson, MD, PhD
    210 Basophilia
    Kathryn Foucar, MD
    212 Lymphocytosis
    Qian-Yun Zhang, MD, PhD
    216 Lymphopenia, Constitutional and Acquired
    Qian-Yun Zhang, MD, PhD
    220 Plasmacytosis of Bone Marrow
    Kathryn Foucar, MD
    228 Hematogones in Bone Marrow
    Devon Chabot-Richards, MD and Kaaren K. Reichard, MD
    238 Lymphoid Aggregates in Bone Marrow
    Kathryn Foucar, MD and Kaaren K. Reichard, MD
    246 Granulomas in Bone Marrow
    Kathryn Foucar, MD

    SECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS

    CONSTITUTIONAL NEUTROPENIAS

    254 Severe Congenital Neutropenia and Cyclic Neutropenia
    David R. Czuchlewski, MD
    258 Shwachman-Diamond Syndrome
    David R. Czuchlewski, MD
    262 Chediak-Higashi Syndrome
    David R. Czuchlewski, MD
    266 Myelokathexis in WHIM Syndrome
    Kathryn Foucar, MD

    CONSTITUTIONAL NEUTROPHIL ANOMALIES

    270 Pelger-Huët Anomaly
    Kathryn Foucar, MD
    274 MYH9-Related Disorders
    David R. Czuchlewski, MD
    278 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation
    David R. Czuchlewski, MD

    SECTION 6: MEGAKARYOCYTIC DISORDERS

    286 Overview of Megakaryocytic Disorders
    Kathryn Foucar, MD, Marian Rollins-Raval, MD, MPH, and Kaaren K. Reichard, MD

    ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

    296 Immune-Mediated Thrombocytopenia
    Kristin Hunt Karner, MD
    302 Hemolytic Uremic Syndrome
    Kristin Hunt Karner, MD
    308 Heparin-Induced Thrombocytopenia (HIT)
    Marian Rollins-Raval, MD, MPH and Evelyn L. Lockhart, MD, MScBMC
    312 Thrombotic Thrombocytopenic Purpura
    Kristin Hunt Karner, MD, Jay S. Raval, MD, and Marian Rollins-Raval, MD, MPH
    316 Pregnancy-Associated Thrombocytopenia
    Kathryn Foucar, MD, Marian Rollins-Raval, MD, MPH, and Evelyn L. Lockhart, MD, MScBMC

    CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

    320 Thrombocytopenia Absent Radius Syndrome
    David R. Czuchlewski, MD
    324 Congenital Amegakaryocytic Thrombocytopenia
    David R. Czuchlewski, MD
    328 Gray Platelet Syndrome
    David R. Czuchlewski, MD
    332 Wiskott-Aldrich Syndrome-Related Disorders
    David R. Czuchlewski, MD
    336 Congenital Thrombotic Thrombocytopenic Purpura
    David R. Czuchlewski, MD

    THROMBOCYTOSIS

    340 Thrombocytosis
    Kristin Hunt Karner, MD

    SECTION 7: INFECTIONS

    346 Overview of Infections
    Carla S. Wilson, MD, PhD and Karissa Culbreath, PhD, D(ABMM)
    350 Hantavirus Pulmonary Syndrome
    Carla S. Wilson, MD, PhD
    354 Human Immunodeficiency Virus
    Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
    364 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
    Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
    374 Parvovirus B19 Infection
    Carla S. Wilson, MD, PhD
    378 Bacterial Infections, Blood and Bone Marrow Features
    Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
    388 Fungal Infections, Blood and Bone Marrow Features
    Mohammad A. Vasef, MD
    394 Helminthic Infections
    Carla S. Wilson, MD, PhD and Karissa Culbreath, PhD, D(ABMM)
    398 Malaria
    Carla S. Wilson, MD, PhD
    406 Other Protozoan Infections
    Karissa Culbreath, PhD, D(ABMM), Kathryn Foucar, MD, and Carla S. Wilson, MD, PhD
    412 COVID-19 Infection (SARS-CoV-2)
    Daniel Babu, MD, Kathryn Foucar, MD, and Karissa Culbreath, PhD, D(ABMM)

    SECTION 8: MISCELLANEOUS NONNEOPLASTIC DISORDERS AND CONDITIONS

    418 Overview and Classification of Hemophagocytic Disorders in Bone Marrow
    Mohammad A. Vasef, MD
    426 Hematologic Manifestations of Collagen Vascular Disorders
    Kristin Hunt Karner, MD
    432 Hematologic Manifestations of Chronic Kidney Disease
    Kathryn Foucar, MD
    434 Lysosomal Storage Diseases With Predominantly Histiocytic Storage
    David R. Czuchlewski, MD
    440 Homeopathic Remedies and Medications Affecting Blood and Bone Marrow Morphology
    Brittany Coffman, MD and Kathryn Foucar, MD
    444 Other Pregnancy-Associated Hematologic Disorders
    Kathryn Foucar, MD
    448 VEXAS Syndrome
    Brittany Coffman, MD and Kathryn Foucar, MD
    452 Gelatinous Transformation and Other Bone Marrow
    Stromal Disorders
    Carla S. Wilson, MD, PhD
    456 Bone Marrow Necrosis
    Kathryn Foucar, MD
    460 Crystals in Bone Marrow
    Carla S. Wilson, MD, PhD
    466 Bone Abnormalities in Bone Marrow Specimens
    Kathryn Foucar, MD

    SECTION 9: MYELOID NEOPLASMS

    476 Overview and Classification of Myeloid Neoplasms
    Kathryn Foucar, MD
    482 Specialized Testing in Myeloid Neoplasms
    David R. Czuchlewski, MD

    MYELOPROLIFERATIVE NEOPLASMS

    484 Overview of Myeloproliferative Neoplasms
    Kathryn Foucar, MD
    488 Chronic Myeloid Leukemia
    Daniel Babu, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
    498 Chronic Neutrophilic Leukemia
    Kathryn Foucar, MD, Devon Chabot-Richards, MD, and Kaaren K. Reichard, MD
    506 Polycythemia Vera
    Mohammad A. Vasef, MD and M. Carmen Frias Kletecka, MD
    512 Primary Myelofibrosis
    Kathryn Foucar, MD, Daniel Babu, MD, and Kaaren K. Reichard, MD
    522 Essential Thrombocythemia
    Kathryn Foucar, MD, Daniel Babu, MD, and Kaaren K. Reichard, MD
    530 Chronic Eosinophilic Leukemia, Not Otherwise Specified
    Kathryn Foucar, MD and Kaaren K. Reichard, MD
    538 Myeloproliferative Neoplasm, Unclassifiable
    Kathryn Foucar, MD and Kaaren K. Reichard, MD

    MASTOCYTOSIS

    544 Systemic Mastocytosis
    Marian Rollins-Raval, MD, MPH and Kaaren K. Reichard, MD
    554 Mast Cell Leukemia
    Marian Rollins-Raval, MD, MPH, Kathryn Foucar, MD, and Kaaren K. Reichard, MD

    MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TYROSINE KINASE GENE FUSIONS

    562 Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRA
    David R. Czuchlewski, MD
    564 Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRB
    David R. Czuchlewski, MD
    566 Myeloid/Lymphoid Neoplasms With Eosinophilia and FGFR1
    David R. Czuchlewski, MD
    568 Myeloid/Lymphoid Neoplasms With Eosinophilia and FLT3 and Other Uncommon Fusion Genes
    Kathryn Foucar, MD and Brittany Coffman, MD

    MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS

    570 Overview of Myelodysplastic/Myeloproliferative Neoplasms
    Kathryn Foucar, MD
    574 Chronic Myelomonocytic Leukemia and Precursor Lesions
    David R. Czuchlewski, MD
    578 Atypical Chronic Myeloid Leukemia
    Qian-Yun Zhang, MD, PhD
    582 Myelodysplastic/Myeloproliferative Neoplasm With and Without SF3B1 Mutation and Thrombocytosis
    Devon Chabot-Richards, MD
    586 Myelodysplastic/Myeloproliferative Neoplasms, Not Otherwise Specified, and Provisional Entity
    Kathryn Foucar, MD

    MYELODYSPLASTIC SYNDROMES

    588 Overview and Classification of Myelodysplastic Syndromes
    Kathryn Foucar, MD
    598 Myelodysplastic Syndrome Precursor Lesions
    Devon Chabot-Richards, MD
    600 Myelodysplastic Syndromes With Mutated SF3B1
    Carla S. Wilson, MD, PhD
    604 Myelodysplastic Syndrome With del(5q)
    Marian Rollins-Raval, MD, MPH and Kaaren K. Reichard, MD
    612 Myelodysplastic Syndrome With Multihit TP53 Mutation
    Devon Chabot-Richards, MD
    614 Myelodysplastic Syndromes, Not Otherwise Specified
    Carla S. Wilson, MD, PhD
    620 Myelodysplastic Syndromes With Excess Blasts
    Carla S. Wilson, MD, PhD
    624 Myelodysplastic Syndrome/Acute Myeloid Leukemia
    Kathryn Foucar, MD
    628 Mimics of Myelodysplasia
    Qian-Yun Zhang, MD, PhD and Brittany Coffman, MD

    HEMATOLOGIC NEOPLASMS WITH GERMLINE PREDISPOSITION, PEDIATRIC MYELODYSPLASTIC SYNDROME, AND JUVENILE MYELOMONOCYTIC LEUKEMIA

    632 Juvenile Myelomonocytic Leukemia and Similar Neoplasms
    Devon Chabot-Richards, MD and Qian-Yun Zhang, MD, PhD
    636 Pediatric Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)
    Carla S. Wilson, MD, PhD
    642 Hematologic Neoplasms With Germline Predisposition
    David R. Czuchlewski, MD
    644 Myeloid Proliferations Related to Down Syndrome
    David R. Czuchlewski, MD

    ACUTE MYELOID LEUKEMIA

    648 Overview of Acute Myeloid Leukemia
    Kathryn Foucar, MD and Kaaren K. Reichard, MD
    656 Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2)/PML::RARA
    Mohammad A. Vasef, MD and Kathryn Foucar, MD
    662 Acute Promyelocytic Leukemia With Other RARA Rearrangements
    Devon Chabot-Richards, MD and Kathryn Foucar, MD
    664 Acute Myeloid Leukemia With t(8;21)(q22;q22.1)/RUNX1::RUNX1T1
    Daniel Babu, MD, Devon Chabot-Richards, MD, and Kaaren K. Reichard, MD
    674 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11
    Daniel Babu, MD, Devon Chabot-Richards, MD, and Kaaren K. Reichard, MD
    682 Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3)/MLLT3::KMT2A and Other
    KMT2A Rearrangements
    Devon Chabot-Richards, MD, Daniel Babu, MD, and Kaaren K. Reichard, MD
    690 Acute Myeloid Leukemia With Mutated TP53
    Kristin Hunt Karner, MD and Kathryn Foucar, MD
    694 Acute Myeloid Leukemia With Uncommon Cytogenetic Abnormalities
    David R. Czuchlewski, MD
    698 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities
    Kathryn Foucar, MD
    704 Acute Myeloid Leukemia, Not Otherwise Specified
    Qian-Yun Zhang, MD, PhD and Kathryn Foucar, MD
    708 Acute Leukemia of Ambiguous Lineage
    Marian Rollins-Raval, MD, MPH, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
    714 Measurable Residual Disease Testing Strategies in
    Acute Myeloid Leukemia
    Brittany Coffman, MD and Kathryn Foucar, MD

    BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM

    718 Blastic Plasmacytoid Dendritic Cell Neoplasm
    Devon Chabot-Richards, MD and Kaaren K. Reichard, MD

    SECTION 10: LYMPHOID NEOPLASMS

    728 Overview of Lymphoid Neoplasms
    Kathryn Foucar, MD
    734 Specialized Testing in Lymphoid Neoplasms
    Brittany Coffman, MD and Devon Chabot-Richards, MD

    B-PRECURSOR NEOPLASMS

    738 B-Acute Lymphoblastic Leukemias: Cytogenetic Subtypes and Not Otherwise Specified (ICC)
    Qian-Yun Zhang, MD, PhD
    746 B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like
    Joanna L. Conant, MD, Devon Chabot-Richards, MD, and Mohammad A. Vasef, MD
    750 Novel Genetic Subtypes of B-Acute Lymphoblastic Leukemia
    Devon Chabot-Richards, MD
    754 Measurable Residual Disease Testing Strategies in Acute Lymphoblastic Leukemia
    David R. Czuchlewski, MD

    T-PRECURSOR NEOPLASMS

    756 T- and NK-Cell Acute Lymphoblastic Leukemia (ICC)
    Mohammad A. Vasef, MD
    762 Early T-Cell Precursor Acute Lymphoblastic Leukemia
    David R. Czuchlewski, MD

    MATURE B-CELL NEOPLASMS

    764 Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Neoplasms
    Kathryn Foucar, MD and Kaaren K. Reichard, MD
    772 Monoclonal B-Cell Lymphocytosis
    Devon Chabot-Richards, MD
    776 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
    Kathryn Foucar, MD
    786 B-Cell Prolymphocytic Leukemia
    Kathryn Foucar, MD
    788 Splenic Marginal Zone Lymphoma
    Qian-Yun Zhang, MD, PhD
    794 Hairy Cell Leukemia
    Kathryn Foucar, MD
    804 Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant
    Kathryn Foucar, MD
    806 Lymphoplasmacytic Lymphoma
    Qian-Yun Zhang, MD, PhD
    812 ?-Heavy Chain Disease
    Kathryn Foucar, MD
    816 Monoclonal Gammopathy
    Carla S. Wilson, MD, PhD
    822 Multiple Myeloma
    Carla S. Wilson, MD, PhD
    834 Burkitt Lymphoma
    Qian-Yun Zhang, MD, PhD
    842 Mantle Cell Lymphoma in Blood and Bone Marrow
    Devon Chabot-Richards, MD
    846 Follicular Lymphoma in Blood and Bone Marrow
    Qian-Yun Zhang, MD, PhD
    850 Marginal Zone Lymphoma in Blood and Bone Marrow
    Devon Chabot-Richards, MD
    854 Intravascular Large B-Cell Lymphoma
    Mohammad A. Vasef, MD
    858 Other Large B-Cell Lymphomas in Blood and Bone Marrow
    Mohammad A. Vasef, MD

    MATURE T-/NK-CELL NEOPLASMS

    860 Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow
    Kathryn Foucar, MD
    864 T-Cell Prolymphocytic Leukemia
    Kathryn Foucar, MD
    870 T-Cell Large Granular Lymphocytic Leukemia
    Kathryn Foucar, MD
    876 Chronic Lymphoproliferative Disorder of NK Cells
    Kathryn Foucar, MD
    878 Aggressive NK-Cell Leukemia
    Kathryn Foucar, MD
    882 Adult T-Cell Leukemia
    Kathryn Foucar, MD
    884 Sézary Syndrome
    Kathryn Foucar, MD
    890 Anaplastic Large Cell Lymphoma in Blood and Bone Marrow
    Mohammad A. Vasef, MD
    896 Angioimmunoblastic T-Cell Lymphoma in Blood and Bone Marrow
    Mohammad A. Vasef, MD
    898 Other Mature T-Cell Lymphomas Involving Blood and Bone Marrow
    Mohammad A. Vasef, MD

    HODGKIN LYMPHOMA IN BONE MARROW

    902 Classic Hodgkin and Nodular Lymphocyte-Predominant B-Cell Lymphomas in Bone Marrow
    Mohammad A. Vasef, MD

    SECTION 11: OTHER NEOPLASMS INVOLVING BONE MARROW

    910 Langerhans Cell Histiocytosis in Bone Marrow
    Mohammad A. Vasef, MD
    914 Posttransplant Lymphoproliferative Disorders in Bone Marrow
    Mohammad A. Vasef, MD
    920 Metastatic Carcinoma and Sarcoma
    Mohammad A. Vasef, MD
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