The new edition of this well-known text is an introduction to general pathology:: a subject that bridges the divide between the basic biological sciences and the practice of clinical medicine. The functional and structural changes that occur in cells and tissues as a result of direct damage by, or reactions to, a wide variety of unfavourable circumstances are described. Full account is taken of the rapidly increasing understanding of the underlying molecular mechanisms.
The nature of pathology Cell injury and its manifestations Cell and tissue death Acute inflammation I: introduction Acute inflammation II: cellular events and chemical mediators Factors that modify the immune response The natural history of acute inflammation I: healing The natural history of acute inflammation II: wound healing The natural history of acute inflammation III: chronicity The immune system Disorders related to the immune system Autoimmune disease Transplantation and the major histocompatability complex Granulomatous inflammation Some specific granulomatous disorders Amyloid and amyloidosis General pathology of viral infections Atherosclerosis Thrombosis Embolism Ischaemia and infarction Abnormal accumulation of fluid and disorders of blood distribution Pigmentation and heterotropic calcification Neoplasia: disorders of cell proliferation and differentiation Non-neoplastic disturbance in cell growth and proliferation Cell proliferation and differentiation in relation to neoplasia Relationship of neoplastic cells with their environment: tumour spread Effects of neoplasms on the host Effect of the host on neoplasms Oncogenesis and the molecular biology of cancer Oncogenesis Genetic disorders Single gene defects
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