Diagnostic Pathology: Genitourinary

SECTION 1: KIDNEY

Introduction and Overview

4 Introduction to Renal Cell Tumors

Satish K. Tickoo, MD and Victor E. Reuter, MD

10 Classification of Kidney Tumors and Tumor-Like Lesions

Satish K. Tickoo, MD and Victor E. Reuter, MD

Familial Cancer Syndromes

12 von Hippel-Lindau Syndrome

Satish K. Tickoo, MD and Victor E. Reuter, MD

16 Birt-Hogg-Dubé Syndrome

Satish K. Tickoo, MD and Victor E. Reuter, MD

20 Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome

Satish K. Tickoo, MD, Victor E. Reuter, MD, and Mahul B. Amin, MD

24 Tuberous Sclerosis Complex

Satish K. Tickoo, MD and Victor E. Reuter, MD

28 Succinate Dehydrogenase Complex Deficiency Syndrome

Satish K. Tickoo, MD and Victor E. Reuter, MD

32 Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes

Satish K. Tickoo, MD and Victor E. Reuter, MD

Nonneoplastic Lesions

38 Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia

Satish K. Tickoo, MD and Victor E. Reuter, MD

Renal Cell Tumors, Benign

44 Papillary Adenoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

48 Renal Oncocytoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

Renal Cell Carcinoma

54 Clear Cell Renal Cell Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

64 Multilocular Cystic Renal Neoplasm of Low Malignant Potential

Satish K. Tickoo, MD and Victor E. Reuter, MD

68 Clear Cell Renal Cancers With Fibromyomatous Stroma, Including ELOC (Formerly TCEB1) Mutated Renal Cell Carcinoma

Judy Sarungbam, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD

74 Clear Cell Papillary Renal Cell Tumor

Satish K. Tickoo, MD and Victor E. Reuter, MD

82 Papillary Renal Cell Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

92 Chromophobe Renal Cell Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

100 Collecting Duct Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

106 SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

112 TFE3- and TFEB-Rearranged Renal Cell Carcinomas

Satish K. Tickoo, MD and Victor E. Reuter, MD

120 Mucinous Tubular and Spindle Cell Carcinoma

Satish K. Tickoo, MD, Yingbei Chen, MD, and Victor E. Reuter, MD

126 Tubulocystic Renal Cell Carcinoma

Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD

130 Thyroid-Like Follicular Carcinoma of Kidney

Satish K. Tickoo, MD and Victor E. Reuter, MD

134 Acquired Cystic Disease-Associated Renal Cell Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

140 Fumarate Hydratase-Deficient Renal Cell Carcinoma

Jatin S. Gandhi, MD and Mahul B. Amin, MD

144 ALK Rearrangement-Associated Renal Cell Carcinoma

Jatin S. Gandhi, MD and Mahul B. Amin, MD

148 Eosinophilic Solid and Cystic Renal Cell Carcinoma

Jatin S. Gandhi, MD and Mahul B. Amin, MD

150 Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT

Satish K. Tickoo, MD and Victor E. Reuter, MD

154 Subsequent 2nd Tumors

Satish K. Tickoo, MD and Victor E. Reuter, MD

158 Renal Cell Carcinoma, Not Otherwise Specified

Satish K. Tickoo, MD and Victor E. Reuter, MD

Metanephric Tumors

162 Metanephric Adenoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

168 Metanephric Tumors Other Than Metanephric Adenoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

Nephroblastic Tumors

172 Nephrogenic Rests

Satish K. Tickoo, MD and Victor E. Reuter, MD

176 Nephroblastoma (Wilms Tumor)

Satish K. Tickoo, MD and Victor E. Reuter, MD

186 Cystic Partially Differentiated Nephroblastoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

Mesenchymal Tumors

188 Angiomyolipoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

194 Epithelioid Angiomyolipoma/Epithelioid PEComa

Satish K. Tickoo, MD and Victor E. Reuter, MD

200 Congenital Mesoblastic Nephroma

Satish K. Tickoo, MD and Victor E. Reuter, MD

204 Clear Cell Sarcoma of Kidney

Satish K. Tickoo, MD and Victor E. Reuter, MD

208 Rhabdoid Tumor of Kidney

Satish K. Tickoo, MD and Victor E. Reuter, MD

Mixed Mesenchymal and Epithelial Tumors

212 Mixed Epithelial and Stromal Tumor (MEST) Family Tumors

Satish K. Tickoo, MD and Victor E. Reuter, MD

220 Pediatric Cystic Nephroma

Satish K. Tickoo, MD and Victor E. Reuter, MD

224 Synovial Sarcoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

Neuroendocrine Tumors

228 Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

232 Renal Ewing Sarcoma

Satish K. Tickoo, MD and Victor E. Reuter, MD

Hematopoietic Tumors

236 Hematopoietic Tumors

Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD

Metastatic and Other Tumors

242 Juxtaglomerular Cell Tumor (Reninoma)

Satish K. Tickoo, MD and Victor E. Reuter, MD

246 Renomedullary Interstitial Cell Tumor

Satish K. Tickoo, MD and Victor E. Reuter, MD

250 Other Rare Tumors

Satish K. Tickoo, MD and Victor E. Reuter, MD

258 Metastatic Tumors

Satish K. Tickoo, MD and Victor E. Reuter, MD

Immunohistochemical Profiles for Tumors Involving Kidney

262 Immunohistochemistry, Kidney

Satish K. Tickoo, MD and Victor E. Reuter, MD

SECTION 2

Introduction and Overview

270 Classification of Bladder Tumors and Tumor-Like Lesions

Steven Christopher Smith, MD, PhD

Microscopic Anatomy

272 Microscopic Anatomy of Urinary Bladder

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

276 Microscopic Anatomy of Urethra

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

280 Microscopic Anatomy of Ureter

Steven Christopher Smith, MD, PhD

282 Microscopic Anatomy of Renal Pelvis

Steven Christopher Smith, MD, PhD

Nonneoplastic Lesions of Urinary Tract

286 Overview of Cystitis

Steven Christopher Smith, MD, PhD

292 Polypoid Cystitis

Steven Christopher Smith, MD, PhD

300 Malakoplakia

Steven Christopher Smith, MD, PhD

306 Schistosomiasis

Steven Christopher Smith, MD, PhD

308 von Brunn Nests

Steven Christopher Smith, MD, PhD

314 Nephrogenic Adenoma (Metaplasia)

Steven Christopher Smith, MD, PhD

322 Fibroepithelial Polyp

Steven Christopher Smith, MD, PhD

326 Prostatic-Type Polyp (Ectopic Prostate)

Steven Christopher Smith, MD, PhD

330 Amyloidosis

Steven Christopher Smith, MD, PhD

332 Müllerian Lesions

Steven Christopher Smith, MD, PhD

336 Pseudocarcinomatous Hyperplasia

Steven Christopher Smith, MD, PhD

344 Hamartoma

Steven Christopher Smith, MD, PhD

Urothelial Neoplasms, General

346 Overview of Urinary Bladder Neoplasms

Hikmat Al-Ahmadie, MD

Flat Urothelial Lesions

350 Urothelial Carcinoma In Situ

Steven Christopher Smith, MD, PhD

358 Flat Urothelial Lesions Other Than Carcinoma In Situ

Steven Christopher Smith, MD, PhD

UROTHELIAL NEOPLASMS, NONINVASIVE

362 Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia)

Jatin S. Gandhi, MD and Mahul B. Amin, MD

364 Urothelial Papilloma

Steven Christopher Smith, MD, PhD

370 Papillary Urothelial Neoplasm of Low Malignant Potential

Steven Christopher Smith, MD, PhD

374 Low-Grade Papillary Urothelial Carcinoma

Hikmat Al-Ahmadie, MD

378 High-Grade Papillary Urothelial Carcinoma

Hikmat Al-Ahmadie, MD

384 Inverted Urothelial Neoplasia

Steven Christopher Smith, MD, PhD

Urothelial Neoplasms, Invasive

394 Invasive Urothelial Carcinoma

Hikmat Al-Ahmadie, MD

404 Urothelial Carcinoma, Subtypes and Divergent Differentiation

Steven Christopher Smith, MD, PhD

Glandular Lesions

426 Cystitis Cystica et Glandularis

Hikmat Al-Ahmadie, MD

430 Villous Adenoma

Hikmat Al-Ahmadie, MD

432 Invasive Adenocarcinoma

Hikmat Al-Ahmadie, MD

438 Clear Cell Adenocarcinoma

Hikmat Al-Ahmadie, MD

Squamous Lesions

444 Squamous Proliferations Other Than Carcinoma

Hikmat Al-Ahmadie, MD

448 Invasive Squamous Cell Carcinoma

Hikmat Al-Ahmadie, MD

Mesenchymal Lesions

454 Myofibroblastic Proliferations

Steven Christopher Smith, MD, PhD

462 Smooth Muscle Tumors

Steven Christopher Smith, MD, PhD

470 Rhabdomyosarcoma

Steven Christopher Smith, MD, PhD

476 Other Mesenchymal Tumors

Steven Christopher Smith, MD, PhD

Other Tumors of Urinary Bladder

484 Paraganglioma

Steven Christopher Smith, MD, PhD

492 Metastatic/Secondary Involvement of Bladder

Steven Christopher Smith, MD, PhD

Diverticula of Urinary Tract

500 Diverticula

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

504 Diverticular-Associated Neoplasia

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

URETHRA

508 Inflammatory Lesions of Urethra

Steven Christopher Smith, MD, PhD

512 Carcinoma of Urethra

Steven Christopher Smith, MD, PhD

516 Other Tumors and Tumor-Like Lesions of Urethra

Steven Christopher Smith, MD, PhD

URETER

520 Urothelial Carcinoma of Ureter

Hikmat Al-Ahmadie, MD

524 Other Tumors and Tumor-Like Lesions of Ureter

Hikmat Al-Ahmadie, MD

RENAL PELVIS

530 Urothelial Carcinoma of Renal Pelvis

Hikmat Al-Ahmadie, MD

540 Other Tumors and Tumor-Like Lesions of Renal elvis

Hikmat Al-Ahmadie, MD

Urachs

546 Urachal Remnants

Steven Christopher Smith, MD, PhD

548 Tumors of Urachus

Steven Christopher Smith, MD, PhD

Immunohistochemical Profiles for Tumors Involving Urinary Bladder

554 Immunohistochemistry, Urinary Tract

Steven Christopher Smith, MD, PhD

SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE

Introduction and Overview

562 Classification of Prostate Tumors and Tumor-Like Lesions

Gladell P. Paner, MD, (BS) MT

564 General Concepts, Prostate

Gladell P. Paner, MD, (BS) MT

570 Microanatomy and Zonal Variations

Gladell P. Paner, MD, (BS) MT

580 Imaging Considerations for Pathologists

Steven Christopher Smith, MD, PhD

NONNEOPLASTIC LESIONS

584 Prostatitis

Steven Christopher Smith, MD, PhD

588 Prostate Hyperplasia

Gladell P. Paner, MD, (BS) MT

596 Adenosis

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

600 Atrophy and Its Patterns

Gladell P. Paner, MD, (BS) MT

606 Hyperplasia of Mesonephric Remnants

Steven Christopher Smith, MD, PhD

610 Verumontanum Mucosal Gland Hyperplasia

Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD

612 Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra

Gladell P. Paner, MD, (BS) MT

PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS

620 Prostatic Intraepithelial Neoplasia

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

Prostate Neoplasms

630 General Concepts, Prostate Carcinoma

Steven Christopher Smith, MD, PhD

638 Acinar Adenocarcinoma

Gladell P. Paner, MD, (BS) MT

656 Acinar Adenocarcinoma Subtypes and Patterns

Gladell P. Paner, MD, (BS) MT

668 Atypical Small Acinar Proliferations

Steven Christopher Smith, MD, PhD

674 Intraductal Proliferations and Ductal Carcinoma

Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD

682 Ductal Adenocarcinoma

Gladell P. Paner, MD, (BS) MT

690 Urothelial Carcinoma Involving Prostate Gland

Steven Christopher Smith, MD, PhD

696 Prostate Carcinoma With Neuroendocrine Differentiation

Steven Christopher Smith, MD, PhD

704 Adenoid Cystic (Basal Cell) Carcinoma of Prostate

Steven Christopher Smith, MD, PhD

710 Sarcomatoid Carcinoma of Prostate

Steven Christopher Smith, MD, PhD

716 Carcinomas With Squamous Differentiation

Gladell P. Paner, MD, (BS) MT

722 Cystic Epithelial Tumors of Prostate

Gladell P. Paner, MD, (BS) MT

724 Stromal Tumors

Gladell P. Paner, MD, (BS) MT

732 Mesenchymal Tumors of Prostate

Gladell P. Paner, MD, (BS) MT

740 Melanocytic Lesions of Prostate

Gladell P. Paner, MD, (BS) MT

744 Hematopoietic Neoplasms of Prostate

Gladell P. Paner, MD, (BS) MT

748 Secondary Tumors of Prostate

Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD

Tumors of Seminal Vesicle

752 Mixed Epithelial and Stromal Tumor

Steven Christopher Smith, MD, PhD

756 Seminal Vesicle Adenocarcinoma

Gladell P. Paner, MD, (BS) MT

Immunohistochemical Profiles for Tumors and Tumor-Like Lesions Involving Prostate Gland

758 Immunohistochemistry, Prostate

Steven Christopher Smith, MD, PhD

SECTION 4: TESTIS AND PARATESTICULAR STRUCTURES

Introduction and Overview

766 Classification of Testis and Paratestis Tumors and Tumor-Like Lesions

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Nonneoplastic Lesions

768 Cryptorchidism

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

772 Sertoli Cell-Only Syndrome

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

776 Nontuberculous Infections

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

778 Nonspecific Granulomatous Orchitis

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

780 Tuberculous Epididymo-Orchitis

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

Germ Cell Tumors

782 General Concepts, Germ Cell Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Germ Cell Tumors Related to Germ Cell Neoplasia In Situ

790 Germ Cell Neoplasia In Situ

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

796 Seminoma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

804 Intratubular Seminoma

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

806 Intratubular Embryonal Carcinoma

Steven S. Shen, MD, PhD

808 Embryonal Carcinoma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

814 Yolk Sac Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

822 Choriocarcinoma and Other Trophoblastic Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

828 Postpubertal-Type Teratoma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

832 Mixed Germ Cell Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

836 Somatic-Type Malignancy in Germ Cell Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

838 Burnt-Out (Regressed) Germ Cell Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Germ Cell Tumors Unrelated to Germ Cell Neoplasia In Situ

840 Spermatocytic Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

844 Pediatric Germ Cell Tumor, General Concepts

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

846 Prepubertal-Type Teratoma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

850 Yolk Sac Tumor, Prepubertal Type

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

854 Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type

Muhammad T. Idrees, MD

856 Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma)

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Sex Cord-/Gonadal Stromal Tumors

860 General Concepts, Sex Cord-/Gonadal Stromal Tumors

Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD

868 Leydig Cell Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD

872 Sertoli Cell Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD

878 Large Cell Calcifying Sertoli Cell Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

882 Intratubular Large Cell Hyalinizing Sertoli Cell Tumor

Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Muhammad T. Idrees, MD

884 Granulosa Cell Tumor

Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Muhammad T. Idrees, MD

888 Juvenile Granulosa Cell Tumor

Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Muhammad T. Idrees, MD

892 Fibroma-Thecoma

Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD

894 Myoid Gonadal Stromal Tumor

Muhammad T. Idrees, MD

896 Signet-Ring Stromal Tumors

Muhammad T. Idrees, MD

898 Testicular Tumor of Adrenogenital Syndrome

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

902 Sex Cord-Stromal Tumor, Mixed/Unclassified

Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and

Muhammad T. Idrees, MD

906 Gonadoblastoma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Hematopoietic Tumors

910 Lymphoma/Leukemia/Plasmacytoma

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

Tumors Of Paratesticular Structures

916 Adenomatoid Tumor

Steven S. Shen, MD, PhD, Jae Y. Ro, MD, PhD, and Muhammad T. Idrees, MD

920 Well-Differentiated Papillary Mesothelial Tumor

Muhammad T. Idrees, MD

922 Malignant Mesothelioma

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

926 Adenocarcinoma of Rete Testis/Epididymis

Steven S. Shen, MD, PhD, Jae Y. Ro, MD, PhD, and Muhammad T. Idrees, MD

928 Epididymal Tumors

Muhammad T. Idrees, MD

930 Ovarian Epithelial-Type Tumors

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

934 Liposarcoma

Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD

940 Melanotic Neuroectodermal Tumor

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

944 Rhabdomyosarcoma

Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD

950 Other Sarcomas

Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD

Metastatic Tumors, Testis and Paratesticular Structures

954 Metastatic Tumors, Testis and Paratesticular Structures

Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD

Immunohistochemical Profiles for Tumors Involving Testis and Paratesticular Structures

958 Immunohistochemistry, Testis

Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD

SECTION 5: PENIS AND SCROTUM

Frequent Lesions of Uncertain Relationship to Penile Neoplasia

968 Condyloma

María José Fernández De Nestosa, PhD

972 Lichen Sclerosus et Atrophicus

Elsa F. Velazquez, MD, Sofía Cańete-Portillo, MD, and Antonio L. Cubilla, MD

974 Squamous Hyperplasia

Sofía Cańete-Portillo, MD, Diego Fernando Sánchez Martínez, MD, and Antonio L. Cubilla, MD

978 Lipogranuloma

Elsa F. Velazquez, MD and Antonio L. Cubilla, MD

980 Scrotal Calcinosis

Elsa F. Velazquez, MD and Antonio L. Cubilla, MD

Penile Intraepithelial Neoplasia

982 Penile Intraepithelial Neoplasia

Elsa F. Velazquez, MD, Diego Fernando Sánchez Martínez, MD, and Antonio L. Cubilla, MD

Primary Epithelial Tumors

988 General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology)

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, Sofía Cańete-Portillo, MD, Mahul B. Amin, MD, and Elsa F. Velazquez, MD

1002 Overview of HPV- and Non-HPV-Related Tumors

María José Fernández De Nestosa, PhD, Diego Fernando Sánchez Martínez, MD, Mahul B. Amin, MD, and Antonio L. Cubilla, MD

Squamous Cell Carcinoma and Its Subtypes

1006 Squamous Cell Carcinoma, Usual Type

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1010 Basaloid Squamous Cell Carcinoma

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1014 Basaloid Squamous Cell Carcinoma, Papillary Subtype

Diego Fernando Sánchez Martínez, MD and Antonio L. Cubilla, MD

1016 Warty (Condylomatous) Squamous Cell Carcinoma

Elsa F. Velazquez, MD, Sofía Cańete-Portillo, MD, and Antonio L. Cubilla, MD

1020 Warty-Basaloid Squamous Cell Carcinoma

Diego Fernando Sánchez Martínez, MD and Antonio L. Cubilla, MD

1022 Verrucous Squamous Cell Carcinoma

Elsa F. Velazquez, MD, Sofía Cańete-Portillo, MD, and Antonio L. Cubilla, MD

1026 Papillary Squamous Cell Carcinoma, Not Otherwise Specified

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1030 Pseudoglandular Squamous Cell Carcinoma

Diego Fernando Sánchez Martínez, MD and Antonio L. Cubilla, MD

1032 Pseudohyperplastic Squamous Cell Carcinoma

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1034 Cuniculatum Squamous Cell Carcinoma

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1038 Sarcomatoid Squamous Cell Carcinoma

Elsa F. Velazquez, MD, Sofía Cańete-Portillo, MD, and Antonio L. Cubilla, MD

1042 Mixed Squamous Cell Carcinoma

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

1046 Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate

Diego Fernando Sánchez Martínez, MD and Antonio L. Cubilla, MD

1048 Clear Cell Carcinoma

Diego Fernando Sánchez Martínez, MD and Antonio L. Cubilla, MD

Other Neoplastic Conditions

1050 Extramammary Paget Disease

Elsa F. Velazquez, MD and Antonio L. Cubilla, MD

1054 Kaposi Sarcoma

Elsa F. Velazquez, MD, Jesse K. McKenney, MD, and

Antonio L. Cubilla, MD

1056 Myointimoma

Mahul B. Amin, MD and Jatin S. Gandhi, MD

Metastatic Tumors

1058 Metastatic Tumors, Penis

Antonio L. Cubilla, MD, Diego Fernando Sánchez Martínez, MD, and Sofía Cańete-Portillo, MD

Immunohistochemical Profiles for Tumors Involving Penis

1060 Immunohistochemistry, Penis

Antonio L. Cubilla, MD