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Molecular Biology and Pathology of Paediatric Cancer

Molecular Biology and Pathology of Paediatric Cancer

9780192630797
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Description
There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focussed on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behaviour of particular cancers and more recently, therecognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers whowish to have an understanding of our current state of knowledge. A international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is a broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. Thefirst section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatriccancers.
Product Details
OUP Oxford
84260
9780192630797
9780192630797

Data sheet

Publication date
2003
Issue number
1
Cover
hard cover
Pages count
360
Dimensions (mm)
196 x 253
Weight (g)
887
  • An introduction to childrens cancer and the patient experience; Section 1:: Methods and Clinical Application; Cells, tissues and the diagnostic laboratory; Methods of genetic analysis applied to paediatric cancer; Blots, dots, amplification and sequencing; Familial and predisposition syndromes; Section 2:: Childhood cancers; Leukaemia; Lymphoma; Tumours of the central nervous system and eye; Neuroblastoma; Primitive neuroectodermal tumours; Rhabdomyosarcoma; Malignant soft tissue tumours of childhood; Pediatric renal neoplasms; Bone tumours (excluding Ewings sarcoma); Germ cell tumours; Liver tumours; Carcinoma; Glossary of molecular terms;
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