This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is writtenby leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapterproviding a detailed background, key recent advances, and areas of doubt and future developments.Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.
1. History, diagnosis, and epidemiology; The history of rheumatoid arthritis; Diagnosis; The descriptive epidemiology of rheumatoid arthritis; Modifiable and other risk factors for rheumatoid arthritis: a basis for prevention and better therapy; 2. Pathogenesis; Genetics and epigenetics of rheumatoid arthritis; Dysregulation of synovial fibroblasts in rheumatoid arthritis; Autoantibodies in rheumatoid arthritis; Dendritic cells and T cells in rheumatoid arthritis; Mechanisms of bone and cartilage destruction; Cytokines and other mediators; 3. Clinical presentation; Clinical features of rheumatoid arthritis; Pre-rheumatoid arthritis; Non-articular manifestations of rheumatoid arthritis; Comorbidity in rheumatoid arthritis; 4. Disease assessment; Disease activity assessment in rheumatoid arthritis; Synovial biopsies; Radiography in rheumatoid arthritis; Ultrasound in rheumatoid arthritis; MRI in rheumatoid arthritis; 5. Impact on life; Patient physical function in rheumatoid arthritis; Fatigue; Health economics; Rheumatoid arthritis and work; 6. Non-drug treatments; Exercise; Foot health; Occupational therapy; Self-management: a patients perspective; 7. Drug treatments; Analgesics, Opioids, and NSAIDs; Glucocorticoids; Conventional disease modifying drugs; Tumour necrosis factor inhibitors; Interleukin-6 inhibitors; B-cell therapies; Biosimilars; Immunogenicity in response to biologic agents; The use of JAK inhibitors in the treatment of rheumatoid arthritis; Combination therapy in rheumatoid arthritis; Translation of new therapies: from bench to bedside; Adverse events in clinical studies in rheumatoid arthritis; 8. Management and outcomes; Prevention of rheumatoid arthritis; Treatment targets and remission; Clinical outcomes; Clinical guidelines; European biologics registers; Voluntary patient registries;
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