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Experimental Research Methods in Orthopedics and Trauma

Experimental Research Methods in Orthopedics and Trauma

9783131731111
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Description

Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma

From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this roadmap at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.

Special Features::

  • Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research
  • Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system
  • Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies - spanning topics from fracture fixation to gait analysis to bone remodeling
  • Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function
  • Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering
  • Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study

With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology, apply its findings, and participate fully in research activities.

Product Details
Georg Thieme
55823
9783131731111
9783131731111

Data sheet

Publication date
2015
Issue number
1
Cover
paperback
Pages count
464
Dimensions (mm)
194.95 x 269.88
Weight (g)
1179

  • Part 1 Why Do We Need Experimental Research?
    1 Evidence-Based Research
    2 Establishing a Basic Research Facility in Orthopedic Surgery
    3 Good Laboratory Practice and Quality Control
    4 How to Prepare for a Period in Research
    Part 2 Structural Biomechanics
    5 Physiological Boundary Conditions for Mechanical Testing
    6 Static, Dynamic, and Fatigue Mechanical Testing
    7 Use of Human and Animal Specimens in Biomechanical Testing
    8 Whole Bone Biomechanics
    9 Biomechanics of Trabecular and Cortical Bone
    10 Biomechanics of Fracture Fixation
    11 Biomechanical Assessment of Fracture Repair
    12 Biomechanics of Cartilage
    13 Biomechanics of Joints
    14 Spine Biomechanics
    Part 3 Functional Biomechanics
    15 Musculokeletal Dynamics
    16 Measurement Techniques
    17 Clinical Assessment of Function
    18 Functional Biomechanics with Cadaver Specimens
    Part 4 Numerical Biomechanics
    19 Inverse Dynamics
    20 Principles of Finite Elements Analysis
    21 Validation of Finite Element Models
    22 Computational Biomechanics of Bone
    23 Numerical Simulation of Implants and Prosthetic Devices
    24 Numerical Simulation of Fracture Healing and Bone Remodelling
    Part 5 Imaging
    25 Micro-Computed Tomography Imaging of Bone Tissue
    26 Imaging Bone
    27 Ultrasound Techniques for Imaging Bone
    28 In Vivo Scanning
    29 Imaging of Cartilage Function
    30 Histochemistry Bone and Cartilage
    31 Immunohistochemistry
    32 Molecular Imaging In Situ Hybridization
    33 Laser Scanning Confocal Microscopy and Laser Microdissection
    34 Image Analysis Histomorphometry Stereology
    Part 6 Cellular Studies
    35 Cell Culture Research
    36 Cartilage Explants and Organ Culture Models
    37 Fluid Flow and Strain in Bone
    38 Biomechanics of Bone Cells
    Part 7 Molecular Techniques in Bone Repair
    39 Molecular Testing
    40 Genetically Modified Models for Bone Repair
    Part 8 In Vivo Models
    41 General Considerations for an In Vivo Model
    42 Animal Models for Bone Healing
    43 Models for Impaired Healing
    44 In Vivo Models for Bone and Joint Infections
    45 In Vivo Models for Articular Cartilage Repair
    46 In Vivo Soft Tissue Models
    Part 9 Tissue Engineering
    47 Scaffolds for Tissue Engineering and Materials for Repair
    48 Use of Growth Factors in Musculoskeletal Research
    49 Stem Cells for Musculoskeletal Repair
    50 Biological Evaluation and Testing of Medical Devices
    Part 10 Statistics for Experimental Research
    51 Study Design
    52 Power and Sample Size Calculation
    53 Nonparametric versus Parametric Tests
    54 How to Limit Bias in Experimental Research

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