Corneal cross-linking represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs’ endothelial dystrophy. The new and expanded second edition provides a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modification of standard protocol for special circumstances. With each chapter being fully updated plus the inclusion of over twenty new chapters that cover the latest advances and future directions, Corneal Cross-Linking, Second Edition will represent the cutting-edge of CXL research and clinical practice.