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Cancer Stem Cells in Lung Cancer

Cancer Stem Cells in Lung Cancer

9781617282959
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Description
Of the many markers for cancer stem cells (CSCs) in lung cancer reported to date, the cell surface antigen CD133, nuclear ß-catenin accumulation, the side population phenotype, and high aldehyde dehydrogenase (ALDH) activity seem to be most reliable. This book reviews the results of studies on lung CSCs and discusses the significance of these markers from a biological, pathological, and clinical viewpoint. Twenty-seven lung cancer cell lines (nine small cell lung carcinoma (SCLC) cell lines and eighteen non-small cell lung carcinoma (NSCLC) cell lines) were examined for mRNA and protein expression and fractions of cells with activity.
Product Details
Nova Science Publishers Inc
73510
9781617282959
9781617282959

Data sheet

Publication date
2011
Issue number
1
Cover
paperback
Pages count
65
Dimensions (mm)
215.00 x 140.00
Weight (g)
106
  • Introduction; Stem Cells in Healthy & Injured Lung; Origin of CSCs in Lung Cancers; CD133; Side Population; Aldehyde Dehydrogenase; Other Lung CSC Markers; Signaling Pathways in CSCs of Lung Cancers; Stem Cells in Healthy & Injured Lung; Other Signaling Pathways & Transcription Factors in Lung CSCs; CSC Niche; Brief Summary of Lung CSC Markers & Potential Problems; ALDH mRNA Expression - Its Correlation with the Most Common CSC Marker CD133; ALDH Protein Expression in Lung Cancer Cell Lines ; ALDH Activity in Lung Cancer Cell Lines ; Primary Structure of ALDH1A1 mRNA; Post-Translational Modification of ALDH1A1 Protein; ALDH Protein Expression in Primary Lung Cancers; Conclusion; Index.
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