Tumour Necrosis Factor (TNF) is a member of a superfamily of proteins, each with 157 amino acids, which induce necrosis (death) of tumour cells and possess a wide range of proinflammatory actions. Tumour necrosis factor is a multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and the function of endothelial cells lining blood vessels. Blocking the action of TNF has been shown to be beneficial in reducing the inflammation in inflammatory diseases such as Crohns disease and rheumatoid arthritis. Inappropriate production of TNF or sustained activation of TNF signalling has been implicated in the pathogenesis of a wide spectrum of human diseases that include cancer, osteoporosis, sepsis, diabetes, and auto-immune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Extensive research within the last two decades has shown that TNF can be a potential therapeutic agent in various diseases. This new important book gathers the latest research from around the globe in this field.
Preface; Tumor Necrosis Factor (TNF) ¨C From Bench to Bedside; Tumour Necrosis Factor Alpha Neutralization in The Medical Management of Crohn Żs Disease; Tumor Necrosis Factor-¦Á and Biliary Tract Diseases; Tumor Necrosis Factor Antagonist Induced Psoriatic Skin Lesions; A New Promising Role of Melatonin in Promoting Tumor Necrosis Factor Toxicity in Cancer Cells; Circulating TNF-¦Á and Oral Health Condition in Elderly Japanese; Tumor Necrotic Factor in T-Cell Disorder:: Hypothesis and Proof of Idea; Tumor Necrotic Factor in Malaria; Tumor Necrosis with Special Reference to Autophagic Cell Death; (Self-Cannibalism) and Xeno-Cannibalism in Gastric Cancer; Tumor Necrosis Factor and Carcinoma by Hepatitis B and C Virus Infection;; Index.
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