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Drug Resistant Neoplasms

Drug Resistant Neoplasms

9781607412557
812.64 zł
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Description
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently, resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells. Studies on the mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and its implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.
Product Details
Nova Science Publishers Inc
72841
9781607412557
9781607412557

Data sheet

Publication date
2010
Issue number
1
Cover
hard cover
Pages count
254
Dimensions (mm)
260.00 x 180.00
Weight (g)
712
  • Preface; Therapeutic Implications of the Intrinsic and Acquired Resistance of Cancer Stem/Progenitor Cells in Inefficacy of Current Cancer Treatments and Disease Relapse; The Role of Tumoural Micro-Environment and its Vasculature on Chemotherapy Drug Resistance:: The Potential for their Modulation to Achieve Therapeutic Gain; Inherent and Microenvironment-Mediated Mechanisms of Drug Resistance; Studies on the Mechanisms of Acquired Resistance to EGFR Tyrosine Kinase Inhibitor Gefitinib in NSCLC Cell Lines:: Evidence that Ligand-Induced Endocytosis of EGFR via the Early/Late Endocytic Pathway is Associated with Gefitinib Sensitivity of NSCLC Cell Line; Targeting Adverse Features of Hormone-Resistant Breast Cancer:: Acquired Endocrine Resistance in Breast Cancer; Systematic Analysis of Patterns of Cross Resistance between Anticancer Agents; Molecular Structure and Energy:: Clinical Importance in Drug Resistant Neoplasms; How to Treat the Drug Resistant Malignancy?; Overcoming Ovarian Cancer Drug Resistance with Phytochemicals and Other Compounds; New Research Communications on Cancer Drug Resistance, Assessment of cancer drug resistance with nuclear medicine images; Index.
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