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Optimum Overall Treatment Time in Radiation Oncology: How to Stop Worrying About Time-Dose Evaluations and Learn to Love Linear

Optimum Overall Treatment Time in Radiation Oncology: How to Stop Worrying About Time-Dose Evaluations and Learn to Love Linear

9781930524736
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229.63 zł Save 25.52 zł Tax included
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Description
The late John Jack Fowler was a busy radiation biology researcher and teacher who wrote 581 papers over the last 65 plus years. He also received nearly every honour the medical physics field can bestow. This book sums up the key concepts relating to optimum fractionation in radiation therapy that interested him throughout his life. Just under 100 pages in length, this book is a quick, informative, and enjoyable read.
Product Details
Eurospan
69013
9781930524736
9781930524736

Data sheet

Publication date
2015
Issue number
1
Cover
paperback
Pages count
93
Dimensions (mm)
152.00 x 229.00
  • Optimum Overall Treatment Time in Radiation Oncology Chapter 1:: The Origins of Linear Quadratics 1.1 A 60+ Year Quest to Find How Fractionation Really Works, 1950 - 2014 1.2 The Linear Quadratic Concept and its Relevance to Clinically Sized Doses in Radiotherapy 1.3 Time to Think Chapter 2:: LQ Modeling 2.1 The Simplest Modeling 2.2 The Seven Steps to Linear Quadratic Heaven:: A Brief Summary 2.3 The Details Chapter 3:: Dose and Effectiveness 3.1 Biologically Effective Dose 3.2 Relative Effectiveness (RE) 3.3 Overall Treatment Time and Tolerances 3.3.1 Late Normal Tissue Complications 3.3.2 Acute Mucosal Tolerance Chapter 4:: Normalized Total Dose 4.1 Converting from BED to NTD or EQD 4.2 Gamma Slopes, the Standard of Prescription of Estimates of BED or NTD 4.3 How to Evaluate a New Schedule - a Summary Chapter 5:: A Review of Schedules 5.1 Some of the Best-known Schedules 5.2 Standard Fractionation 5.3 Hyperfractionation 5.4 RTOG 90-03 5.5 Initially Too Hot in Table 5 - 1 5.6 General Considerations 5.7 The Danish Six Fractions a Week 5.8 Appropriateness of LQ Modeling Chapter 6:: How to Obtain Curves with Peaks of Optimum Overall Treatment Times 6.1 Differences Between 7 Days and 3 - 4 Weeks in T k 6.2 The Problem of Finding an Optimum Overall Time Chapter 7:: Time and Repopulation 7.1 Results vs Days of Overall Time 7.1.1 Two Fractions a Day Give More Tumor Log Cell Kill than One Fraction a Day 7.1.2 The Effect of Assuming Faster or Slower Repopulating Rates 7.2 Discussion:: The Exceptional Cases of Very Fast Repopulation Chapter 8:: Should We Ever Use One Fraction a Day? 8.1 Discussion:: Is One Fraction a Day Still to Be Used? 8.2 Main Conclusions 8.2.1 Conclusion #1:: 2F/Day is Nearly Always Better than 1F/Day 8.2.2 Conclusion #2:: Investigate Repopulation Rates for Use in Longer Schedules 8.3 Discussion:: Smaller and Smaller Fractions 8.4 Discussion:: How Long Is Really Too Long? Chapter 9:: How Short is Too Short? 9.1 Introduction 9.2 Acute Tolerance Calculations Are Also Worth Doing Chapter 10:: Recovery 10.1 Incomplete Recovery 10.2 Incomplete Recovery as a Loss of Effect in Prolonged Fractions Chapter 11:: The Influence of Inter-patient Heterogeneity 11.1 Introduction 11.2 Tumor Control Probability Modeling 11.3 Results and Discussion 11.4 Summary Chapter 12:: Final Thoughts Photographs Glossary References and Additional Resources
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